Maybe the test case is to delete one chromosome and insert another a chromosome in a fruit fly. Only 4 pairs of chromosomes, already used for genetic modifications with CRISPR
Goal = complete the insertion and still develop a normal fruit fly. I bet this is a fairly inexpensive experiment, within reach of many people on LessWrong
That implies the ability to mix and match human chromosomes commercially is really far off
I agree that the issues of avoiding damage and having the correct epigenetics seem like huge open questions, and successfully switching a fruit fly chromosome isn’t sufficient to settle them
Would this sequence be sufficient?
1. Switch a chromosome in a fruit fly
Success = normal fruit fly development
2a. Switch a chromosome in a rat
Success = normal rat development
2b. (in parallel, doesn’t depend on 2a) Combine several chromosomes in a fruit fly to optimize aggressively for a particular trait
Success = fruit fly develops with a lot of the desired trait, but without serious negative consequences
3. Repeat 2b on a rat
4. Repeat 2a and 2b on a primate
Can you think of a faster way? It seems like a very long time to get something commercially viable