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Aging

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Core Path­ways of Aging

johnswentworthMar 28, 2021, 12:31 AM
274 points
129 comments22 min readLW link1 review

Anti-Aging: State of the Art

JackHDec 31, 2020, 7:07 PM
375 points
176 comments11 min readLW link1 review

Aging and the gero­science hypothesis

DirectedEvolutionJul 12, 2023, 7:16 AM
54 points
14 comments5 min readLW link

Why SENS makes sense

emanuele ascaniFeb 22, 2020, 4:28 PM
28 points
2 comments31 min readLW link

Thoughts on be­ing mortal

Joe CarlsmithJan 1, 2021, 7:17 PM
83 points
5 comments6 min readLW link

Cry­on­ics and Regret

MvBJul 24, 2023, 9:16 AM
190 points
35 comments2 min readLW link1 review

Why We Age, Part 1: What age­ing is and is not

willbradshawMay 24, 2020, 9:06 AM
55 points
5 comments7 min readLW link
(apomorphic.com)

[Question] Why is loss of mus­cle cells not con­sid­ered one of the hal­l­marks of ag­ing?

ChristianKlJan 5, 2021, 2:19 PM
11 points
9 comments1 min readLW link

High­lights of Com­par­a­tive and Evolu­tion­ary Aging

johnswentworthMay 22, 2020, 5:01 PM
56 points
10 comments2 min readLW link

Pro­ject Pro­posal: Gears of Aging

johnswentworthMay 9, 2020, 6:47 PM
58 points
43 comments7 min readLW link

Bryan John­son and a search for healthy longevity

NancyLebovitzJul 27, 2024, 3:28 PM
18 points
17 comments1 min readLW link

Hy­poth­e­sis: lab mice have more ac­tive trans­posons then wild mice

ChristianKlJun 5, 2021, 12:36 PM
20 points
14 comments1 min readLW link

Should we vac­ci­nate against PGBD5 which codes for a trans­posase?

ChristianKlJun 8, 2021, 7:22 PM
18 points
5 comments1 min readLW link

Homeosta­sis and “Root Causes” in Aging

johnswentworthJan 5, 2020, 6:43 PM
86 points
25 comments3 min readLW link

Ad­den­dum to “Amy­loid Plaques: Med­i­cal Good­hart, Chem­i­cal Streetlight”

J BostockSep 2, 2021, 5:42 PM
10 points
1 comment2 min readLW link

How much should we value life?

Adam ZernerSep 6, 2021, 10:30 PM
30 points
25 comments38 min readLW link

[Question] Does any­one have an anki deck on age­ing /​ re­ju­ve­na­tion biotech­nol­ogy that they could share?

freedomandutilityOct 10, 2021, 4:54 PM
1 point
0 comments1 min readLW link

Night­clubs in Heaven?

J BostockNov 5, 2021, 11:28 PM
10 points
3 comments2 min readLW link

The Lens, Proge­rias and Polycausality

johnswentworthMar 8, 2020, 5:53 PM
71 points
8 comments3 min readLW link

Se­cond-or­der se­lec­tion against the immortal

MalmesburyDec 3, 2021, 5:01 AM
45 points
47 comments6 min readLW link

In­ter­net Liter­acy Atrophy

ElizabethDec 26, 2021, 12:30 PM
111 points
49 comments3 min readLW link
(acesounderglass.com)

Adap­tive Im­mune Sys­tem Aging

johnswentworthMar 13, 2020, 3:47 AM
75 points
9 comments3 min readLW link

If you want to live longer, be­come President

BezziFeb 11, 2022, 11:14 PM
8 points
11 comments7 min readLW link

Wormy the Worm

River LewisMay 21, 2022, 3:34 PM
3 points
23 comments5 min readLW link
(heytraveler.substack.com)

[Preprint for com­ment­ing] Fight­ing Aging as an Effec­tive Altru­ism Cause

avturchinApr 16, 2018, 1:55 PM
9 points
5 comments1 min readLW link

Age changes what you care about

DentinOct 16, 2022, 3:36 PM
141 points
37 comments2 min readLW link

Im­mor­tal­ity: A Prac­ti­cal Guide

G0W51Jan 26, 2015, 4:17 PM
53 points
62 comments36 min readLW link

SENS and Givewell: Con­ver­sa­tion be­tween Holden Karnofsky and Aubrey de Grey

curiousepicMar 5, 2013, 7:24 PM
30 points
12 comments12 min readLW link

(Anti)Aging 101

George3d6Mar 12, 2025, 3:59 AM
5 points
2 comments3 min readLW link
(cerebralab.com)

Pre­dic­tion mar­ket: Will John Went­worth’s Gears of Aging se­ries hold up in 2033?

tailcalledFeb 25, 2023, 8:15 PM
15 points
4 comments1 min readLW link
(manifold.markets)

Liv­ing For­ever is Hard, part 2: Adult Longevity

gwernSep 9, 2011, 6:52 PM
20 points
11 comments2 min readLW link

Why We Age, Part 2: Non-adap­tive theories

willbradshawMay 26, 2020, 5:41 PM
89 points
22 comments11 min readLW link
(apomorphic.com)

Com­pres­sion of morbidity

DirectedEvolutionJul 12, 2023, 3:26 PM
12 points
0 comments3 min readLW link

The Foun­tain of Health: a First Prin­ci­ples Guide to Rejuvenation

PhilJacksonJan 7, 2023, 6:34 PM
115 points
38 comments41 min readLW link

[Question] Why ra­tio­nal­ists are not much con­cerned about mor­tal­ity?

SurvivalBiasFeb 10, 2022, 12:11 AM
18 points
92 comments1 min readLW link

Here’s Why In­definite Life Ex­ten­sion Will Never Work, Even Though it Does.

HomingHamsterJun 4, 2024, 6:48 PM
−13 points
5 comments18 min readLW link

Beyond Bio­mark­ers: Un­der­stand­ing Mul­tis­cale Causality

Matěj NekoranecJul 7, 2024, 9:56 AM
13 points
0 comments7 min readLW link

“The Sin­gu­lar­ity Is Nearer” by Ray Kurzweil—Review

LavenderJul 8, 2024, 9:32 PM
22 points
0 comments4 min readLW link

Many life-sav­ing drugs fail for lack of fund­ing. But there’s a solu­tion: des­per­ate rich people

MvolzMar 12, 2025, 3:24 PM
17 points
0 comments1 min readLW link
(www.theguardian.com)

Wrinkles

johnswentworthNov 19, 2019, 10:59 PM
81 points
14 comments4 min readLW link

Liv­ing For­ever is Hard, or, The Gom­pertz Curve

gwernMay 17, 2011, 9:08 PM
67 points
87 comments3 min readLW link

Longevity in­ter­ven­tions when young

George3d6Jul 24, 2020, 11:25 AM
45 points
17 comments39 min readLW link
(cerebralab.com)

In­tro­duc­ing the Longevity Re­search Institute

sarahconstantinMay 8, 2018, 3:30 AM
54 points
20 comments1 min readLW link
(srconstantin.wordpress.com)

In­tro­duc­ing the Longevity Re­search Institute

sarahconstantinDec 14, 2018, 8:20 PM
79 points
11 comments1 min readLW link
(srconstantin.wordpress.com)

Lifeism in the midst of death

TobyBartelsDec 9, 2012, 1:28 PM
97 points
19 comments4 min readLW link

Does Age Bring Wis­dom?

Scott AlexanderNov 8, 2017, 7:20 AM
37 points
9 comments4 min readLW link
(slatestarcodex.com)

Why peo­ple want to die

PhilGoetzAug 24, 2015, 8:13 PM
93 points
174 comments2 min readLW link

Are healthy choices effec­tive for im­prov­ing live ex­pec­tancy any­more?

Christopher KingMay 8, 2023, 9:25 PM
4 points
4 comments1 min readLW link

Hu­man perfor­mance, psy­chom­e­try, and base­ball statistics

Craig_HeldrethOct 15, 2010, 1:13 PM
33 points
21 comments6 min readLW link

Naked mole-rats: A case study in biolog­i­cal weirdness

eukaryoteMay 19, 2019, 6:40 PM
95 points
14 comments3 min readLW link
(eukaryotewritesblog.com)

An alarm­ing fact about the anti-ag­ing community

diegocaleiroFeb 16, 2015, 5:49 PM
44 points
65 comments2 min readLW link

[LINK] Larry = Harry sans magic? Google vs. Death

ShmiSep 18, 2013, 4:49 PM
36 points
55 comments1 min readLW link

Do not miss the cut­off for im­mor­tal­ity! There is a prob­a­bil­ity that you will live for­ever as an im­mor­tal su­per­in­tel­li­gent be­ing and you can in­crease your odds by con­vinc­ing oth­ers to make achiev­ing the tech­nolog­i­cal sin­gu­lar­ity as quickly and safely as pos­si­ble the col­lec­tive goal/​pro­ject of all of hu­man­ity, Similar to “Fable of the Dragon-Tyrant.”

Oliver--KlozoffJun 29, 2023, 3:45 AM
1 point
0 comments28 min readLW link

[Question] What to make of Aubrey de Grey’s pre­dic­tion?

Rafael HarthFeb 28, 2020, 7:25 PM
23 points
18 comments1 min readLW link

BHTV: de Grey and Yudkowsky

Eliezer YudkowskyDec 13, 2008, 3:28 PM
10 points
12 comments1 min readLW link

Book re­view: Age Later

PeterMcCluskeyOct 27, 2020, 4:21 AM
28 points
3 comments4 min readLW link
(www.bayesianinvestor.com)

Im­pact of ag­ing re­search be­sides LEV

emanuele ascaniJun 6, 2019, 10:42 AM
15 points
0 comments7 min readLW link

Three Open Prob­lems in Aging

johnswentworthNov 7, 2020, 7:39 PM
48 points
8 comments5 min readLW link

If calorie re­stric­tion works in hu­mans, should we have ob­served it already?

Mark_EichenlaubApr 24, 2012, 4:28 AM
32 points
33 comments1 min readLW link

Aging: A Sur­pris­ingly Tractable Problem

QuinnApr 8, 2021, 7:25 PM
11 points
0 comments1 min readLW link

[linkpost] Pro­ject Blueprint: ‘Mea­sur­ing and then max­i­mally re­vers­ing the quan­tified biolog­i­cal age of my or­gans’

matteodimaioNov 16, 2021, 2:48 AM
2 points
0 comments1 min readLW link

Aldix and the Book of Life

villeJan 1, 2024, 5:23 PM
1 point
0 comments4 min readLW link
(medium.com)

Be­ing a donor for Fe­cal Micro­biota Trans­plants (FMT): Do good & earn easy money (up to 180k/​y)

EternallyBlissfulJul 8, 2022, 6:17 AM
36 points
26 comments8 min readLW link
(forum.effectivealtruism.org)

(DIY) FMT for Anti-Aging & Biohacking

EternallyBlissfulNov 28, 2022, 3:49 PM
26 points
7 comments6 min readLW link
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