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Aging

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Core Path­ways of Aging

johnswentworth28 Mar 2021 0:31 UTC
265 points
126 comments22 min readLW link1 review

Anti-Aging: State of the Art

JackH31 Dec 2020 19:07 UTC
373 points
176 comments11 min readLW link1 review

Aging and the gero­science hypothesis

DirectedEvolution12 Jul 2023 7:16 UTC
54 points
14 comments5 min readLW link

Thoughts on be­ing mortal

Joe Carlsmith1 Jan 2021 19:17 UTC
83 points
5 comments6 min readLW link

Why SENS makes sense

emanuele ascani22 Feb 2020 16:28 UTC
28 points
2 comments31 min readLW link

[Question] Why is loss of mus­cle cells not con­sid­ered one of the hal­l­marks of ag­ing?

ChristianKl5 Jan 2021 14:19 UTC
11 points
9 comments1 min readLW link

High­lights of Com­par­a­tive and Evolu­tion­ary Aging

johnswentworth22 May 2020 17:01 UTC
56 points
10 comments2 min readLW link

Pro­ject Pro­posal: Gears of Aging

johnswentworth9 May 2020 18:47 UTC
58 points
43 comments7 min readLW link

Bryan John­son and a search for healthy longevity

NancyLebovitz27 Jul 2024 15:28 UTC
18 points
17 comments1 min readLW link

Homeosta­sis and “Root Causes” in Aging

johnswentworth5 Jan 2020 18:43 UTC
86 points
25 comments3 min readLW link

The Lens, Proge­rias and Polycausality

johnswentworth8 Mar 2020 17:53 UTC
71 points
8 comments3 min readLW link

Hy­poth­e­sis: lab mice have more ac­tive trans­posons then wild mice

ChristianKl5 Jun 2021 12:36 UTC
19 points
14 comments1 min readLW link

Should we vac­ci­nate against PGBD5 which codes for a trans­posase?

ChristianKl8 Jun 2021 19:22 UTC
18 points
5 comments1 min readLW link

Adap­tive Im­mune Sys­tem Aging

johnswentworth13 Mar 2020 3:47 UTC
75 points
9 comments3 min readLW link

Ad­den­dum to “Amy­loid Plaques: Med­i­cal Good­hart, Chem­i­cal Streetlight”

J Bostock2 Sep 2021 17:42 UTC
10 points
1 comment2 min readLW link

How much should we value life?

Adam Zerner6 Sep 2021 22:30 UTC
30 points
25 comments38 min readLW link

[Question] Does any­one have an anki deck on age­ing /​ re­ju­ve­na­tion biotech­nol­ogy that they could share?

freedomandutility10 Oct 2021 16:54 UTC
1 point
0 comments1 min readLW link

Night­clubs in Heaven?

J Bostock5 Nov 2021 23:28 UTC
10 points
3 comments2 min readLW link

[Preprint for com­ment­ing] Fight­ing Aging as an Effec­tive Altru­ism Cause

avturchin16 Apr 2018 13:55 UTC
9 points
5 comments1 min readLW link

Se­cond-or­der se­lec­tion against the immortal

Malmesbury3 Dec 2021 5:01 UTC
45 points
47 comments6 min readLW link

In­ter­net Liter­acy Atrophy

Elizabeth26 Dec 2021 12:30 UTC
111 points
49 comments3 min readLW link
(acesounderglass.com)

Im­mor­tal­ity: A Prac­ti­cal Guide

G0W5126 Jan 2015 16:17 UTC
53 points
62 comments36 min readLW link

If you want to live longer, be­come President

Bezzi11 Feb 2022 23:14 UTC
8 points
11 comments7 min readLW link

Wormy the Worm

River Lewis21 May 2022 15:34 UTC
3 points
23 comments5 min readLW link
(heytraveler.substack.com)

Age changes what you care about

Dentin16 Oct 2022 15:36 UTC
141 points
37 comments2 min readLW link

SENS and Givewell: Con­ver­sa­tion be­tween Holden Karnofsky and Aubrey de Grey

curiousepic5 Mar 2013 19:24 UTC
30 points
12 comments12 min readLW link

Liv­ing For­ever is Hard, part 2: Adult Longevity

gwern9 Sep 2011 18:52 UTC
20 points
11 comments2 min readLW link

Pre­dic­tion mar­ket: Will John Went­worth’s Gears of Aging se­ries hold up in 2033?

tailcalled25 Feb 2023 20:15 UTC
15 points
4 comments1 min readLW link
(manifold.markets)

Why We Age, Part 2: Non-adap­tive theories

willbradshaw26 May 2020 17:41 UTC
89 points
22 comments11 min readLW link
(apomorphic.com)

Why We Age, Part 1: What age­ing is and is not

willbradshaw24 May 2020 9:06 UTC
55 points
5 comments7 min readLW link
(apomorphic.com)

Com­pres­sion of morbidity

DirectedEvolution12 Jul 2023 15:26 UTC
12 points
0 comments3 min readLW link

Cry­on­ics and Regret

MvB24 Jul 2023 9:16 UTC
187 points
34 comments2 min readLW link

The Foun­tain of Health: a First Prin­ci­ples Guide to Rejuvenation

PhilJackson7 Jan 2023 18:34 UTC
114 points
38 comments41 min readLW link

[Question] Why ra­tio­nal­ists are not much con­cerned about mor­tal­ity?

SurvivalBias10 Feb 2022 0:11 UTC
18 points
92 comments1 min readLW link

Here’s Why In­definite Life Ex­ten­sion Will Never Work, Even Though it Does.

HomingHamster4 Jun 2024 18:48 UTC
−13 points
5 comments18 min readLW link

Beyond Bio­mark­ers: Un­der­stand­ing Mul­tis­cale Causality

Matěj Nekoranec7 Jul 2024 9:56 UTC
13 points
0 comments7 min readLW link

“The Sin­gu­lar­ity Is Nearer” by Ray Kurzweil—Review

Lavender8 Jul 2024 21:32 UTC
22 points
0 comments4 min readLW link

Wrinkles

johnswentworth19 Nov 2019 22:59 UTC
81 points
14 comments4 min readLW link

Liv­ing For­ever is Hard, or, The Gom­pertz Curve

gwern17 May 2011 21:08 UTC
67 points
87 comments3 min readLW link

Longevity in­ter­ven­tions when young

George3d624 Jul 2020 11:25 UTC
45 points
17 comments39 min readLW link
(cerebralab.com)

In­tro­duc­ing the Longevity Re­search Institute

sarahconstantin8 May 2018 3:30 UTC
54 points
20 comments1 min readLW link
(srconstantin.wordpress.com)

In­tro­duc­ing the Longevity Re­search Institute

sarahconstantin14 Dec 2018 20:20 UTC
79 points
11 comments1 min readLW link
(srconstantin.wordpress.com)

Lifeism in the midst of death

TobyBartels9 Dec 2012 13:28 UTC
97 points
19 comments4 min readLW link

Does Age Bring Wis­dom?

Scott Alexander8 Nov 2017 7:20 UTC
37 points
8 comments4 min readLW link
(slatestarcodex.com)

Why peo­ple want to die

PhilGoetz24 Aug 2015 20:13 UTC
93 points
174 comments2 min readLW link

Are healthy choices effec­tive for im­prov­ing live ex­pec­tancy any­more?

Christopher King8 May 2023 21:25 UTC
6 points
4 comments1 min readLW link

Hu­man perfor­mance, psy­chom­e­try, and base­ball statistics

Craig_Heldreth15 Oct 2010 13:13 UTC
33 points
21 comments6 min readLW link

Naked mole-rats: A case study in biolog­i­cal weirdness

eukaryote19 May 2019 18:40 UTC
95 points
14 comments3 min readLW link
(eukaryotewritesblog.com)

An alarm­ing fact about the anti-ag­ing community

diegocaleiro16 Feb 2015 17:49 UTC
44 points
65 comments2 min readLW link

[LINK] Larry = Harry sans magic? Google vs. Death

Shmi18 Sep 2013 16:49 UTC
36 points
55 comments1 min readLW link

Do not miss the cut­off for im­mor­tal­ity! There is a prob­a­bil­ity that you will live for­ever as an im­mor­tal su­per­in­tel­li­gent be­ing and you can in­crease your odds by con­vinc­ing oth­ers to make achiev­ing the tech­nolog­i­cal sin­gu­lar­ity as quickly and safely as pos­si­ble the col­lec­tive goal/​pro­ject of all of hu­man­ity, Similar to “Fable of the Dragon-Tyrant.”

Oliver--Klozoff29 Jun 2023 3:45 UTC
1 point
0 comments28 min readLW link

[Question] What to make of Aubrey de Grey’s pre­dic­tion?

Rafael Harth28 Feb 2020 19:25 UTC
23 points
18 comments1 min readLW link

BHTV: de Grey and Yudkowsky

Eliezer Yudkowsky13 Dec 2008 15:28 UTC
10 points
12 comments1 min readLW link

Book re­view: Age Later

PeterMcCluskey27 Oct 2020 4:21 UTC
28 points
3 comments4 min readLW link
(www.bayesianinvestor.com)

Im­pact of ag­ing re­search be­sides LEV

emanuele ascani6 Jun 2019 10:42 UTC
15 points
0 comments7 min readLW link

Three Open Prob­lems in Aging

johnswentworth7 Nov 2020 19:39 UTC
48 points
8 comments5 min readLW link

If calorie re­stric­tion works in hu­mans, should we have ob­served it already?

Mark_Eichenlaub24 Apr 2012 4:28 UTC
32 points
33 comments1 min readLW link

Aging: A Sur­pris­ingly Tractable Problem

Quinn8 Apr 2021 19:25 UTC
11 points
0 comments1 min readLW link

[linkpost] Pro­ject Blueprint: ‘Mea­sur­ing and then max­i­mally re­vers­ing the quan­tified biolog­i­cal age of my or­gans’

matteodimaio16 Nov 2021 2:48 UTC
2 points
0 comments1 min readLW link

Aldix and the Book of Life

ville1 Jan 2024 17:23 UTC
1 point
0 comments4 min readLW link
(medium.com)

Be­ing a donor for Fe­cal Micro­biota Trans­plants (FMT): Do good & earn easy money (up to 180k/​y)

EternallyBlissful8 Jul 2022 6:17 UTC
36 points
26 comments8 min readLW link
(forum.effectivealtruism.org)

(DIY) FMT for Anti-Aging & Biohacking

EternallyBlissful28 Nov 2022 15:49 UTC
26 points
7 comments6 min readLW link
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