Those are all good points. One problem is that when the parasitic class prints itself a few trillion, it justifies it by also doing tax-supported “rescues” of obsolete companies, a terrible idea as your second paragraph implies.
William Walker
Karma: 39
You could say the same about WW2… and a lot of idiots have. Trillions of dollars worth of destruction (mostly from the “recovery programs”, aka bailout opportunities grabbed by the upper-class twits) does not help anyone achieve any legitimate goals.
Those who talk about “less materialism” while supporting transfer programs from my barely solvent self to them can stuff it.
I’d accept the “practice for a more serious pandemic” one… that’s true. Problem is that there is no sign of anyone working on stopping FDA and CDC from banning PCR kits for the NEXT epidemic either… in fact, they’ll both get big budget boosts from the publicity they’ve generated by making it impossible to even LOOK for the virus until late March for most places...
Thanks!
(?) This is LessWrong… I thought everyone was either rich enough to sub to the big papers, or clever enough to get around the paywalls? If I had known that this club was going to accept me as a member, I shouldn’t have joined!
Yes, I’ve been working from home since March, so have “ramped up physical training” in the sense that the borderline-personality collie demands that I run 20 miles per day now ;)
Although vaccines won’t be available, there are other strategies available now that can reduce severity. One is NAD+ boosting, that ameliorates the single biggest defect in old cells, the downregulation of PARP10:
https://www.ispot.tv/ad/nq4g/tru-niagen-immense-energy
You girls all seem like normal nerds, what’s the issue ;)
I get the “need equipment the right size” thing, our gun range keeps some short LOP stocks around for any women that wants to take up shooting.
BTW, I was told to learn to cook so I didn’t starve to death… not sure that was actually some kind of gender abuse ;)
I did not know that… I can’t spare many neurons, I’d better check it out.
The apoptosis pathway requires the mitochondria to be on… this has been noted since Warburg in 1935 (look up Warburg Effect).
More likely that NR would enable apoptosis to work correctly. Most of the time. Anything can happen with freakin’ aneuploid cells, but that’s how I would bet. Also, try to stop cells from going aneuploid in first place… this came up in the early days of telomerase research. Lengthening telomeres “sounds” like it would increase cancer, but it doesn’t, if it’s just from temporary activation (and I dunno why, but lengthening telomeres lenthens lifespans even in animals like mice with crazy long telomeres and telomerase on in every single cell).
Lengthening telomeres in mid-life actually prevents end-fusion events which can make cells go totally wacky (BTW, I hate using aneuploids like HeLa and then claiming you’ve said something about human cells… I’ve looked at thousands of those things in the cyto lab, and they ain’t even slightly human.)
More from Brenner on SARS-CoV-2 and NAD+:
https://twitter.com/CharlesMBrenner/status/1251813463581736961
Curve keeps dropping, hopefully this virus is as seasonal as most of its kind:
Thanks for clearing that up for me, I’ve read LessWrong for years but haven’t tried to post much before the virus gave me some free time, I’m still getting used to the format.
You’re right, you can overlap Phases if the FDA cooperates.
In 1957 they put together a flu vaccine in four months.
Of course, in 1969 we had flight-ready NERVA nuclear rocket engines. In 1962, Orion was ready for nuclear flight… progress doesn’t always go in a straight line.
Least of all in biotech, where our incentives are so twisted that we use the most dangerous treatments first.
Moderna says they’ll have their RNA vaccine in production by July, BTW. And there are safer treatments under study:
https://www.biorxiv.org/content/10.1101/2020.04.17.047480v1
Look up how much vitamin D you get from an hour of full-body sun exposure… if Vitamin D weakened defense against SARS-CoV-2 (instead of helping, as it does against other viruses), the Australians and Indians would have trouble ;)
...when actually they’re doing much better than the US.
One thing we can do is eliminate inventory taxes… this is one reason that companies were forced into just-in-time. We currently punish people for being prepared for any emergency ;)
Thanks! Fixed now.
Sure, that’s why he disclosed. (Although you’re incorrect about “profitable”, so far ;)
But the Sinclair lab at Harvard hates Brenner, Iowa, and apple pie, yet came to similar conclusions:
https://www.preprints.org/manuscript/202004.0548/v1
As far as lung health goes, tuberculosis prevalence is inversely correlated with B3 (of any kind, not just NR). This isn’t some $@#! malaria drug or Ebola has-been, there’s no side-effect downside.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825668/
As someone who was immortalizing various cells with telomerase vectors in 2001 in the Shay-Wright lab, it’s shocking to see the lack of study of telomerase activation. In 2020, you can either take Centella asiatica and astragalus like a Taoist monk, or you can use AAV-vector telomerase with no idea what it will do (it’s probably not a great idea, since only rodents keep their telomerase on...)
Where are all the billionaires into cryonics that we see on Futurama (which is itself getting old...)
Agree with the Vitamin D, C, and zinc. Also take nicotinamide riboside (a B3 variant) to raise PARP10 levels. (Recent paper on this):
https://www.biorxiv.org/content/10.1101/2020.04.17.047480v2
And don’t forget to stagger around the neighborhood biting everyone… millions of movie fans have been waiting for this for decades.
Is anyone using the short school day /two classes method? Given how the Finnish system works, it sounds promising.
Re susceptibility to SARS-CoV-2, I think this paper has a lot of the answer, especially for older people:
https://www.biorxiv.org/content/10.1101/2020.04.17.047480v2
Look at how declining NAD+ levels in age shut down the cellular innate immunity system… it automatically kills off the old during epidemics.
And yes, this is another attempt by me to get you to pay attention to the recent developments in NAD+ boosting vs. coronavirus… there’s finally a human trial on this in Denmark. Everyone please try to live long enough to worry about aging ;)
https://clinicaltrials.gov/ct2/history/NCT04407390?V_1=View#StudyPageTop