Excellent article! I agree with your thesis, and you’ve presented it very clearly.
I largely agree that we cannot outsource knowledge. For example, you cannot outsource the knowledge to play the violin, and you must invest in countless hours of deliberate practice to learn to play the violin.
A rule of thumb I like is only to delegate things that you know how to do yourself. A successful startup founder is capable of comfortably stepping into the shoes of anyone they delegate work to. Otherwise, they would have no idea what high-quality work looks like and how long work is expected to take. The same perspective applies to wanting to cure ageing with an investment of a billion dollars. If you don’t know how to do the work yourself, you have little chance of successfully delegating that work.
Do you think outsourcing knowledge to experts would be more feasible if we had more accurate and robust mechanisms for distinguishing the real experts from the noise?
I bet that most of them would replicate flawlessly. Boring lab techniques and protein structure dominate the list, nothing fancy or outlandish. Interestingly, the famous papers like relativity, expansion of the universe, the discovery of DNA etc. don’t rank anywhere near the top 100. There is also a math paper on fuzzy sets among the top 100. Now that’s a paper that definitely replicates!