If both of these are correct (IgG4 doesn’t prevent clearing of the virus or increase severity relative to other antibody profiles), then it seems to me that there should be no problem. However, I don’t see a citation for the “not seen clinically” claim, which raises a question as to how I’m to interpret it:
If it means that Sabina Vohra-Miller has seen an actual study that compared people with high IgG4 vs others and found that high IgG4 was not associated with any less effective clearance of the virus, and either forgot to cite it or I missed it among the other references, that would be reassuring.
If it means that Sabina Vohra-Miller looked diligently for any study that would find a result either way, and didn’t find any, or didn’t look and just assumed that she would be aware of any effect if found, that would be much less reassuring.
Since Sabina Vohra-Miller’s citations were inconveniently in image form, included below to save anyone else from OCR’ing or typing them out:
Ok, found a twitter thread which includes the claims:
and
If both of these are correct (IgG4 doesn’t prevent clearing of the virus or increase severity relative to other antibody profiles), then it seems to me that there should be no problem. However, I don’t see a citation for the “not seen clinically” claim, which raises a question as to how I’m to interpret it:
If it means that Sabina Vohra-Miller has seen an actual study that compared people with high IgG4 vs others and found that high IgG4 was not associated with any less effective clearance of the virus, and either forgot to cite it or I missed it among the other references, that would be reassuring.
If it means that Sabina Vohra-Miller looked diligently for any study that would find a result either way, and didn’t find any, or didn’t look and just assumed that she would be aware of any effect if found, that would be much less reassuring.
Since Sabina Vohra-Miller’s citations were inconveniently in image form, included below to save anyone else from OCR’ing or typing them out:
(I found the link to the above twitter thread from a comment at this antivax substack)