“Pigs may have been chosen due to the fact that they are especially resistant to prion disease.”
I assume you’re talking about the original selection of pig brains as the source of Cerebrolysin in 1951. This is entirely impossible, as prions were unknown in 1951. The only prion disease known at the time was scrapie in sheep, but of course they didn’t know what caused it.
You have an eagle eye Carl!… I actually asked Claude (the AI) about this when I was writing it, but I was very sloppy and didn’t read Claude’s answer carefully. Just fixed it. I should be more careful..
Uh this is kinda embarrassing but I just didn’t really read it at all honestly..
Q: when was prion disease discovered
A: “Prion disease was first recognized as a distinct category of neurodegenerative disorders in the 1980s, though the groundwork for its discovery was laid earlier.
Key milestones in the discovery of prion diseases include:
1920s: Creutzfeldt-Jakob Disease (CJD) was first described by Hans Gerhard Creutzfeldt and Alfons Maria Jakob.
1950s: Carleton Gajdusek began studying kuru, a disease affecting the Fore people of Papua New Guinea.
1960s: Gajdusek demonstrated that kuru could be transmitted to chimpanzees, suggesting an infectious etiology.
1982: Stanley Prusiner coined the term “prion” (for proteinaceous infectious particle) and proposed the protein-only hypothesis for these infectious agents.
1997: Prusiner was awarded the Nobel Prize in Physiology or Medicine for his work on prions.
The concept of prions as the causative agents of these diseases was revolutionary because it challenged the central dogma of biology, suggesting that proteins alone, without nucleic acids, could be infectious.
Would you like me to elaborate on any specific aspect of prion disease discovery?”
“Pigs may have been chosen due to the fact that they are especially resistant to prion disease.”
I assume you’re talking about the original selection of pig brains as the source of Cerebrolysin in 1951. This is entirely impossible, as prions were unknown in 1951. The only prion disease known at the time was scrapie in sheep, but of course they didn’t know what caused it.
You have an eagle eye Carl!… I actually asked Claude (the AI) about this when I was writing it, but I was very sloppy and didn’t read Claude’s answer carefully. Just fixed it. I should be more careful..
I’m a little confused. Is Claude considered a reliable secondary source now? Did you not even check Wikipedia?
I’m as enthusiastic about the power of AI as the next guy, but that seems like the worst possible way to use it.
Claude is fine if you ask him to cite his sources since you won’t be directly relying on Claude. It’s still prudent to check the sources.
What did Claude say, exactly?
Uh this is kinda embarrassing but I just didn’t really read it at all honestly..
Q: when was prion disease discovered
A: “Prion disease was first recognized as a distinct category of neurodegenerative disorders in the 1980s, though the groundwork for its discovery was laid earlier.
Key milestones in the discovery of prion diseases include:
1920s: Creutzfeldt-Jakob Disease (CJD) was first described by Hans Gerhard Creutzfeldt and Alfons Maria Jakob.
1950s: Carleton Gajdusek began studying kuru, a disease affecting the Fore people of Papua New Guinea.
1960s: Gajdusek demonstrated that kuru could be transmitted to chimpanzees, suggesting an infectious etiology.
1982: Stanley Prusiner coined the term “prion” (for proteinaceous infectious particle) and proposed the protein-only hypothesis for these infectious agents.
1997: Prusiner was awarded the Nobel Prize in Physiology or Medicine for his work on prions.
The concept of prions as the causative agents of these diseases was revolutionary because it challenged the central dogma of biology, suggesting that proteins alone, without nucleic acids, could be infectious.
Would you like me to elaborate on any specific aspect of prion disease discovery?”