This is obviously not a very realistic model, but it probably produces fairly realistic results. But again, this is an area for future improvement.
Curious from a modeling perspective: what improvements would be top of mind for you? Another way to phrase this: if someone else were to try modeling this, what aspects would you look at to tell if it’s an improvement or not?
Curious from a modeling perspective: what improvements would be top of mind for you? Another way to phrase this: if someone else were to try modeling this, what aspects would you look at to tell if it’s an improvement or not?
allow multiple causal variants per clump
more realistic linkage disequilibrium structure
more realistic effect size and allele frequency distributions
it’s not actually clear to me the current ones aren’t realistic, but this could be better informed by data
this might require better datasets
better estimates of SNP heritability and number of causal variants
we just used some estimates which are common in the literature (but there’s a pretty big range of estimates in the literature)
this also might require better datasets