I think it most definitely would. Broda Barnes didn’t like it, but only because the test is stressful and so tends to give false negatives (you’re looking for the resting rate). But as long as it’s done carefully, it should be fine.
The resting VO2 will need to be post-processed to be a diagnostic indicator. A brief look indicates that it is a function of sex (higher in men), age (higher in younger people), and weight. Might be a function of physical fitness (or at least lean body mass) as well.
Yes, sorry, thank you. The important quantity would be metabolic rate divided by the best prediction from the known relevant variables, as you say. It was once a test for hypothyroidism, so whatever the last word pre-blood test was should be good enough.
As I say, Broda Barnes found this test wanting and preferred waking axillary temperature (for females, on the correct days; for males, anytime), but it should be plenty good enough to establish that there’s something funny going on. The problem is to draw the attention of medical science to it at all. I trust them to sort out the details.
The problem is to draw the attention of medical science to it at all.
You are digging into this problem and I suspect there’s enough published data on RMR (resting metabolic rate) in healthy and not-so-healthy people to collate some interesting evidence.
Agree, we should be able to refute it or strongly support it from the published literature. My initial attempts at that look like refutation. How can fibromyalgia in Turkish women be associated with HIGHER body temperature if my hypotheses are true?
And I wonder if there are enough Less Wrong readers with friends with these diseases to make a survey of some sort?
Oh, and I predict that the resting VO2 would be normally distributed, but with a skew towards low values, and the size of that skew should be directly related to the size of the problem.
And that low VO2 should correlate strongly with cholesterol, fatigue, blah, blah, blah.
And I’ve got no idea whether that’s true. It’s a prediction.
I predict that the resting VO2 would be normally distributed
Well… Technically speaking, that’s impossible because normal distribution is defined on the negative infinity to positive infinity range. So there should be some kind of a bounded bell-shaped distribution, might be a truncated normal but I have no idea whether to expect heavy or light tails.
A paper reports that for the sample size of 535 people they have the mean of 241 ml/min with the standard deviation of 56.6. They have some graphs and eyeballing them the observed minimum is around 100 and the observed maximum is about 450 -- that indicates a bit of a right-hand skew. But their population is not normal, their sample is basically cardiac patients.
You can go chase the references in that paper. At least one90543-6/fulltext) looks promising.
I think it most definitely would. Broda Barnes didn’t like it, but only because the test is stressful and so tends to give false negatives (you’re looking for the resting rate). But as long as it’s done carefully, it should be fine.
The resting VO2 will need to be post-processed to be a diagnostic indicator. A brief look indicates that it is a function of sex (higher in men), age (higher in younger people), and weight. Might be a function of physical fitness (or at least lean body mass) as well.
Yes, sorry, thank you. The important quantity would be metabolic rate divided by the best prediction from the known relevant variables, as you say. It was once a test for hypothyroidism, so whatever the last word pre-blood test was should be good enough.
As I say, Broda Barnes found this test wanting and preferred waking axillary temperature (for females, on the correct days; for males, anytime), but it should be plenty good enough to establish that there’s something funny going on. The problem is to draw the attention of medical science to it at all. I trust them to sort out the details.
You are digging into this problem and I suspect there’s enough published data on RMR (resting metabolic rate) in healthy and not-so-healthy people to collate some interesting evidence.
Agree, we should be able to refute it or strongly support it from the published literature. My initial attempts at that look like refutation. How can fibromyalgia in Turkish women be associated with HIGHER body temperature if my hypotheses are true?
And I wonder if there are enough Less Wrong readers with friends with these diseases to make a survey of some sort?
That’s not how you find patients a lot of patients. It makes more sense to seek online communitites where people with the illnesses congregate.
There’s the patientslikeme forum: https://www.patientslikeme.com/forum/fibromyalgia/topics
http://www.fibromyalgiaforums.org/
http://www.healingwell.com/community/?f=24
Oh, and I predict that the resting VO2 would be normally distributed, but with a skew towards low values, and the size of that skew should be directly related to the size of the problem.
And that low VO2 should correlate strongly with cholesterol, fatigue, blah, blah, blah.
And I’ve got no idea whether that’s true. It’s a prediction.
Well… Technically speaking, that’s impossible because normal distribution is defined on the negative infinity to positive infinity range. So there should be some kind of a bounded bell-shaped distribution, might be a truncated normal but I have no idea whether to expect heavy or light tails.
A paper reports that for the sample size of 535 people they have the mean of 241 ml/min with the standard deviation of 56.6. They have some graphs and eyeballing them the observed minimum is around 100 and the observed maximum is about 450 -- that indicates a bit of a right-hand skew. But their population is not normal, their sample is basically cardiac patients.
You can go chase the references in that paper. At least one90543-6/fulltext) looks promising.