Two years later, there are now whole brain wide recordings on C. Elegans via calcium imaging. This includes models apparently at least partially predictive of behavior and analysis of individual neuron contributions to behavior.
If you want the “brain-wide recordings and accompanying behavioral data” you can apparently download them here!
It is very exciting to finally have measurements for this. I still need to do more than skim the paper though. While reading it, here are the questions on my mind:
* What are the simplest individual neuron models that properly replicates each measured neuron-activation? (There are different cell types so take that into account too)
* If you run those individually measurement-validated neuron models forward in time, do they collectively produce the large scale behavior seen?
* If not, why not? What’s necessary?
* Are these calcium imaging measurements sufficient to construct the above? (Assume individualized connectomes per-worm are gathered prior instead of using averages across population)
* If not, what else is necessary?
* And if it is sufficient, how do you construct the model parameters from the measurements?
* Can we now measure and falsify our models of individual neuron learning?
* If we need something else, what is that something?
Edit: apparently Gwern is slightly ahead of me and pointed at Andrew Leifer whose group an entire year ago who produced a functional atlas of C Elegans that also included calcium imaging. Which I’d just totally missed. One missing element is extrasynaptic signaling, which apparently has a large impact on C Elegans behavior. So in order to predict neuron behavior you need to attend to those as well.
My purchase of an arduino kit at the end of highschool. This has essentially passively introduced me to a lot of basic electronics over the years without explicitly studying them. And so now I sometimes think “I want to measure my heart rate” or “I want to build a DIY custom keyboard” or “I want a physical pomodoro timer with just one button and 3 LEDs” and I can just order some parts, build the thing, and have a new tool that solves a simple problem.
I sometimes try to recommend other people build something simple with electronics occasionally, only to realize that they don’t even have any kind of microcontroller. Whereas for me it has become nearly as primitive an action as ‘make a simple bash/python script for this.’ Having the ability to produce electronics has opened up a multitude of solutions that I didn’t even quite realize until I noticed other people getting stuck without this capacity.
The mere presence of electronics in my life encouraged acquiring many other small pieces of knowledge such as what a diode is and why it is useful. What a transistor actually is (which I had theoretically learned in college, but when I needed to make an electrically controlled switch ‘transistor’ did not come to mind as a thing I could buy at the store). This also led to some skills like learning to solder and desolder, and learning to use a 3D printer. Which also was a massive boon that deserves its own answer.