The occasional contrarians who mount fundamental criticism do this with a tacit understanding that they’ve destroyed their career prospects in the academia and closely connected institutions, and they are safely ignored or laughed off as crackpots by the mainstream. (To give a concrete example, large parts of economics clearly fit this description.)
I don’t find this example concrete. I know very little about economics ideology. Can you give more specific examples?
What’s your break even point for “bring 100 trillion fantastic lives into being with probability p” vs. “improve the quality of a single malaria patient” and why?