I agree that brain rejuvenation should be a priority (but alas we live in a world where rejuvenation of any kind is not a mainstream priority). But I feel like all your examples miss the mark? Head transplants just move the brain to a new body, they don’t do anything to reverse the brain’s own aging. The other examples in part II are about trying to migrate the mind out of the brain entirely. What about just trying to rejuvenate the actual neurons?
If you look up brain rejuvenation, the most effective thing known seems to be young blood; so I guess Peter Thiel was on to something. But for those of us who can’t or don’t want to do that, well, this article has a list of “twelve hallmarks of mammalian ageing: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation and dysbiosis”. Logically, we need something like Aubrey de Grey’s SENS, tackling each of these processes, specifically in the context of the human brain. And I would start by browsing the articles on the brain at fightaging.org.
I think the point is being missed here, I’m saying if you solve aging at the level of a head now body-transplant becomes viable, otherwise you’re indeed just stuck with an old mind.
As for parabiosis approaches, the sens take, etc—My personal take is that it’s hogwashy, biology is a faulty paradigm that hasn’t yielded relevant results in 80+ years, primary gains in solving diseases come from diagnosis criteria being shifted, gains in mortality reduction are solving at the mean not at the edges (e.g. removing pollution, better ERs, broader vaccine and antibiotic distribution, reduction in youths dying, reduced childhood mortality—stuff that is a distribution and production problem as of 100 years ago, not a scientific venture)
I agree that brain rejuvenation should be a priority (but alas we live in a world where rejuvenation of any kind is not a mainstream priority). But I feel like all your examples miss the mark? Head transplants just move the brain to a new body, they don’t do anything to reverse the brain’s own aging. The other examples in part II are about trying to migrate the mind out of the brain entirely. What about just trying to rejuvenate the actual neurons?
If you look up brain rejuvenation, the most effective thing known seems to be young blood; so I guess Peter Thiel was on to something. But for those of us who can’t or don’t want to do that, well, this article has a list of “twelve hallmarks of mammalian ageing: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation and dysbiosis”. Logically, we need something like Aubrey de Grey’s SENS, tackling each of these processes, specifically in the context of the human brain. And I would start by browsing the articles on the brain at fightaging.org.
I think the point is being missed here, I’m saying if you solve aging at the level of a head now body-transplant becomes viable, otherwise you’re indeed just stuck with an old mind.
As for parabiosis approaches, the sens take, etc—My personal take is that it’s hogwashy, biology is a faulty paradigm that hasn’t yielded relevant results in 80+ years, primary gains in solving diseases come from diagnosis criteria being shifted, gains in mortality reduction are solving at the mean not at the edges (e.g. removing pollution, better ERs, broader vaccine and antibiotic distribution, reduction in youths dying, reduced childhood mortality—stuff that is a distribution and production problem as of 100 years ago, not a scientific venture)