Black Swan considerations definitely apply here. Although as far as I know, we haven’t had a vaccine that outright killed the majority of the people taking it, it’s not impossible. Maybe it’s just rare enough that we haven’t established a meaningful base rate. You’d also want to be concerned about the possibility of interactions from giving multiple vaccines to one person.
It might make sense to do something like vaccinating populations in the hardest-hit areas first, trying new vaccines as they become available, prioritizing the safest and most effective vaccines as data emerges.
Black Swan considerations definitely apply here. Although as far as I know, we haven’t had a vaccine that outright killed the majority of the people taking it, it’s not impossible. Maybe it’s just rare enough that we haven’t established a meaningful base rate. You’d also want to be concerned about the possibility of interactions from giving multiple vaccines to one person.
It might make sense to do something like vaccinating populations in the hardest-hit areas first, trying new vaccines as they become available, prioritizing the safest and most effective vaccines as data emerges.