I’m especially curious about the second one. Is there any known situation where we have a 3-dimensional arrangement but not the sequence? I can think of two possibilities: either we have an existing protein for which we know the structure but not the sequence (which from my modest understanding looks improbable, because sequence seems easier) or we have an application (medical for example) that needs a specific kind of structure, and we want to know how to create such a protein.
I would mostly be thinking of engineering novel proteins. That field is pretty rudimentary (though the work of Michael Hecht at Princeton fascinates me).
Cool ideas!
I’m especially curious about the second one. Is there any known situation where we have a 3-dimensional arrangement but not the sequence? I can think of two possibilities: either we have an existing protein for which we know the structure but not the sequence (which from my modest understanding looks improbable, because sequence seems easier) or we have an application (medical for example) that needs a specific kind of structure, and we want to know how to create such a protein.
Are these what you had in mind?
I would mostly be thinking of engineering novel proteins. That field is pretty rudimentary (though the work of Michael Hecht at Princeton fascinates me).