That implies the ability to mix and match human chromosomes commercially is really far off
I agree that the issues of avoiding damage and having the correct epigenetics seem like huge open questions, and successfully switching a fruit fly chromosome isn’t sufficient to settle them
Would this sequence be sufficient?
1. Switch a chromosome in a fruit fly Success = normal fruit fly development
2a. Switch a chromosome in a rat Success = normal rat development
2b. (in parallel, doesn’t depend on 2a) Combine several chromosomes in a fruit fly to optimize aggressively for a particular trait Success = fruit fly develops with a lot of the desired trait, but without serious negative consequences
3. Repeat 2b on a rat
4. Repeat 2a and 2b on a primate
Can you think of a faster way? It seems like a very long time to get something commercially viable
It seems fairly straightforward to test whether a chromosome transfer protocol results in physical/genetic damage in small scale experiments (e.g. replace chromosome X in cell A with chromosome Y in cell B, culture cell A, examine cell A’s chromosomes under a microscope + sequence the genome).
The epigenetics seems harder. Having a good gears-level understanding of the epigenetics of development seems necessary, because then you’d know what to measure in an experiment to test whether your protocol was epigenetically sound.
That implies the ability to mix and match human chromosomes commercially is really far off
I agree that the issues of avoiding damage and having the correct epigenetics seem like huge open questions, and successfully switching a fruit fly chromosome isn’t sufficient to settle them
Would this sequence be sufficient?
1. Switch a chromosome in a fruit fly
Success = normal fruit fly development
2a. Switch a chromosome in a rat
Success = normal rat development
2b. (in parallel, doesn’t depend on 2a) Combine several chromosomes in a fruit fly to optimize aggressively for a particular trait
Success = fruit fly develops with a lot of the desired trait, but without serious negative consequences
3. Repeat 2b on a rat
4. Repeat 2a and 2b on a primate
Can you think of a faster way? It seems like a very long time to get something commercially viable
It seems fairly straightforward to test whether a chromosome transfer protocol results in physical/genetic damage in small scale experiments (e.g. replace chromosome X in cell A with chromosome Y in cell B, culture cell A, examine cell A’s chromosomes under a microscope + sequence the genome).
The epigenetics seems harder. Having a good gears-level understanding of the epigenetics of development seems necessary, because then you’d know what to measure in an experiment to test whether your protocol was epigenetically sound.