There has been some serious progress in the last few years on full functional imaging of the C. elegans nervous system (at the necessary spatial and temporal resolutions and ranges).
However, despite this I haven’t been able to find any publications yet where full functional imaging is combined with controlled cellular-scale stimulation (e.g. as I proposed via two-photon excitation of optogenetic channels), which I believe is necessary for inference of a functional model.
There has been some serious progress in the last few years on full functional imaging of the C. elegans nervous system (at the necessary spatial and temporal resolutions and ranges).
A good summary of the state of play as of late 2020 can be found in this opinion article: https://www.sciencedirect.com/science/article/pii/S0959438820301689
State-of-the-art work is currently happening in Shanghai, Hefei, Wuhan, and Beijing. See https://doi.org/10.1002/cyto.a.24483 and https://arxiv.org/pdf/2109.10474.pdf
However, despite this I haven’t been able to find any publications yet where full functional imaging is combined with controlled cellular-scale stimulation (e.g. as I proposed via two-photon excitation of optogenetic channels), which I believe is necessary for inference of a functional model.