Like I guess the main method one can use is to start with the symptoms and track backwards step by step along the known causes of such symptoms to identify causes that are out of whack, until one gets up to some major cause that’s treatable?
Alternatively, one could just throw stuff at the wall and see if it sticks, but it seems like it would be too noisy to work.
The tricky part is I’d think it’s very hard to enumerate the causes of the symptoms? What does it look like in practice?
Here’s one example. Jeff Wood had been suffering from ME/CFS for a while, and found that his head started sinking one day, and a lot of his symptoms would get worse depending on the position of his head/neck. This led to his diagnosis of CCI/AAI and he was able to get the right surgeries and is now in remission. Of course, most of us are not as lucky as he is in having something that so dramatically and immediately changes symptoms. But I think it’s one way to solve such medical mysteries, and is basically what you say about tracking backwards from symptoms to causes.
Here’s another example, although this one hasn’t led to any actual cures yet. Robert Phair used his knowledge of biochemistry pathways to come up with a hypothesis of how the citric acid cycle gets shunted, which has the immediate effect of lowering ATP production but also some other crazy downstream effects like neurotransmitters being stolen to fuel an alternative cyclic reactions (which possibly is what one type of brainfog is caused by). So this approach is more top-down: start with a bunch of “textbook” knowledge and theory, try to come up with a hypothesis of how that could lead to problems, and how those problems might explain symptoms.
What methods do you use to study this?
Like I guess the main method one can use is to start with the symptoms and track backwards step by step along the known causes of such symptoms to identify causes that are out of whack, until one gets up to some major cause that’s treatable?
Alternatively, one could just throw stuff at the wall and see if it sticks, but it seems like it would be too noisy to work.
The tricky part is I’d think it’s very hard to enumerate the causes of the symptoms? What does it look like in practice?
Here’s one example. Jeff Wood had been suffering from ME/CFS for a while, and found that his head started sinking one day, and a lot of his symptoms would get worse depending on the position of his head/neck. This led to his diagnosis of CCI/AAI and he was able to get the right surgeries and is now in remission. Of course, most of us are not as lucky as he is in having something that so dramatically and immediately changes symptoms. But I think it’s one way to solve such medical mysteries, and is basically what you say about tracking backwards from symptoms to causes.
Here’s another example, although this one hasn’t led to any actual cures yet. Robert Phair used his knowledge of biochemistry pathways to come up with a hypothesis of how the citric acid cycle gets shunted, which has the immediate effect of lowering ATP production but also some other crazy downstream effects like neurotransmitters being stolen to fuel an alternative cyclic reactions (which possibly is what one type of brainfog is caused by). So this approach is more top-down: start with a bunch of “textbook” knowledge and theory, try to come up with a hypothesis of how that could lead to problems, and how those problems might explain symptoms.
I’m sure there are many other approaches.