Yeah, of course it affects gene regulation. I’m saying that—maayybe—nature has specific broad patterns of gene expression associated with powerful cognition (mainly, creativity and learning in childhood); and since these are implemented as GRNs, they’ll have small, discoverable on-off switches. You’re copying nature’s work about how to tune a brain to think/learn/create. With ultrasound, my impression is that you’re kind of like “ok, I want to activate GABA neurons in this vague area of the temporal cortex” or “just turn off the amygdala for a day lol”. You’re trying to figure out yourself what blobs being on and off is good for thinking; and more importantly you have a smaller action space compared to signaling molecules—you can only activate / deactivate whatever patterns of gene expression happen to be bundled together in “whatever is downstream of nuking the amygdala for a day”.
Yeah, of course it affects gene regulation. I’m saying that—maayybe—nature has specific broad patterns of gene expression associated with powerful cognition (mainly, creativity and learning in childhood); and since these are implemented as GRNs, they’ll have small, discoverable on-off switches. You’re copying nature’s work about how to tune a brain to think/learn/create. With ultrasound, my impression is that you’re kind of like “ok, I want to activate GABA neurons in this vague area of the temporal cortex” or “just turn off the amygdala for a day lol”. You’re trying to figure out yourself what blobs being on and off is good for thinking; and more importantly you have a smaller action space compared to signaling molecules—you can only activate / deactivate whatever patterns of gene expression happen to be bundled together in “whatever is downstream of nuking the amygdala for a day”.