This is true, but the farther out into the tails of the distribution we get the more likely we are to see negative effects that from traits that aren’t part of the index we’re selecting on.
True, but we wouldn’t need to strictly select for G by association with IQ via GWASes. I suspect G variation is largely driven by mutation load, in which case simply replacing each rare variant with one of its more common counterparts should give you a huge boost while essentially ruling out negative pleiotropy. To hedge your bets you’d probably want to do a combined approach.
I guess there’s some risk that rare variants are involved in people who, e.g., tend to take x-risk very seriously, but I doubt this. I suspect that, to whatever extent this is heritable, it’s controlled by polygenic variation over relatively common variants at many loci. So if you started out with the genomes of people who care lots about x-risk and then threw out all the rare variants, I predict you’d end up with hugely G boosted people who are predisposed to care about x-risk.
As you pointed out, this is moot if genome synthesis is out of reach.
I mostly think the value would be in more actual understanding of alignment difficulties among people working on AI capabilities.
True, but we wouldn’t need to strictly select for G by association with IQ via GWASes. I suspect G variation is largely driven by mutation load, in which case simply replacing each rare variant with one of its more common counterparts should give you a huge boost while essentially ruling out negative pleiotropy. To hedge your bets you’d probably want to do a combined approach.
I guess there’s some risk that rare variants are involved in people who, e.g., tend to take x-risk very seriously, but I doubt this. I suspect that, to whatever extent this is heritable, it’s controlled by polygenic variation over relatively common variants at many loci. So if you started out with the genomes of people who care lots about x-risk and then threw out all the rare variants, I predict you’d end up with hugely G boosted people who are predisposed to care about x-risk.
As you pointed out, this is moot if genome synthesis is out of reach.
Seems sensible.