So in subjects I know a lot about, I have dealt with many people who pick up strange notions by filling in the gaps from google and wikipedia with a weak foundation. The work required to effectively figure out what specific damage to the specific proteins you mentioned could be done by desiccation of a cell is beyond my knowledge base, so I leave it to someone more knowledgeable than myself(perhaps you?) to step in.
What open/closed states does PKMζ have? What regulates those open/closed states? Are the open/closed states important to its roll (it looks like yes given the notion of the inhibitor?)?
Yes, it’s important to build a strong foundation before establishing firm opinions. Also, in this particular case note that science appears to have recently changed it’s mind based on further evidence, which goes to show that you have to be careful when reading wikipedia. Apparently the protein in question is not so likely to underlie LTM after all, as transgenic mice lacking it still have LTM (exhibiting maze memory, LTP, etc). The erasure of memory is linked to zeta inhibitory peptide (ZIP), which incidentally happens in the transgenic mice as well.
ETA: Apparently PKMzeta can be used to restore faded memories erased with ZIP.
So in subjects I know a lot about, I have dealt with many people who pick up strange notions by filling in the gaps from google and wikipedia with a weak foundation. The work required to effectively figure out what specific damage to the specific proteins you mentioned could be done by desiccation of a cell is beyond my knowledge base, so I leave it to someone more knowledgeable than myself(perhaps you?) to step in.
What open/closed states does PKMζ have? What regulates those open/closed states? Are the open/closed states important to its roll (it looks like yes given the notion of the inhibitor?)?
Yes, it’s important to build a strong foundation before establishing firm opinions. Also, in this particular case note that science appears to have recently changed it’s mind based on further evidence, which goes to show that you have to be careful when reading wikipedia. Apparently the protein in question is not so likely to underlie LTM after all, as transgenic mice lacking it still have LTM (exhibiting maze memory, LTP, etc). The erasure of memory is linked to zeta inhibitory peptide (ZIP), which incidentally happens in the transgenic mice as well.
ETA: Apparently PKMzeta can be used to restore faded memories erased with ZIP.