“Shut up and calculate” no longer suffices when you want to figure out something about reality that is not about prediction of observations (or if you are interested in unusual kinds of reality, where even prediction of observations looks unlike it does in our world). So this concerns many philosophical questions, in particular decision theory (where you want to figure out what to do and how to think about what to do). The relationship with decision theory is the same as with physics: you want to replace reality with something more specific. But if you haven’t found a sufficiently good replacement, forcing a bad replacement is worse than fumbling with the preformal idea of reality.
“Shut up and calculate” no longer suffices when you want to figure out something about reality that is not about prediction of observations (or if you are interested in unusual kinds of reality, where even prediction of observations looks unlike it does in our world). So this concerns many philosophical questions, in particular decision theory (where you want to figure out what to do and how to think about what to do). The relationship with decision theory is the same as with physics: you want to replace reality with something more specific. But if you haven’t found a sufficiently good replacement, forcing a bad replacement is worse than fumbling with the preformal idea of reality.