Whatever happened to orexin and the sleep peptide research, anyway? This feels like the first time I’ve heard about it since 2014, but I didn’t hear about any crippling side-effects or big failure to replicates (of the sort that have seriously hampered interest in oxytocin). Did DARPA just stop funding it and no one else stepped in?
We still felt sleepy, though.
How did the feeling compare to modafinil, if you’ve tried all-nighters with that? With modafinil, I always characterized it as not so much that you felt sleepy as that you felt irritated, like “butter scraped over too much bread”, in Bilbo Baggins’s phrase.
From my email exchange with Deadwyler, I took away that DARPA lost interest, and Deadwyler himself disappeared to go work for tobacco companies. And because orexin occurs naturally in the brain, it can’t be patented, which means that it’s hard to make money on it.
(I would expect a snortable cure for sleep would be worth something regardless, but I’m not a pharma company, so what do I know.)
Felt very different from modafinil; on a moda all-nighter I feel just mostly normal, kinda headachey, and a numbed fatigue. On orexin I still felt like I hadn’t slept; let me paste in my journal entry from that day (which is, to my great consternation, literally the only note which remains from this experiment).
“Feel spacey and out of it. More so than I did earlier, though that might just be that I’m interacting with people now. Also hungry. More hungry than warranted? Not sure. Had a mealsquare around… 9? 10?
Whatever happened to orexin and the sleep peptide research, anyway? This feels like the first time I’ve heard about it since 2014, but I didn’t hear about any crippling side-effects or big failure to replicates (of the sort that have seriously hampered interest in oxytocin). Did DARPA just stop funding it and no one else stepped in?
How did the feeling compare to modafinil, if you’ve tried all-nighters with that? With modafinil, I always characterized it as not so much that you felt sleepy as that you felt irritated, like “butter scraped over too much bread”, in Bilbo Baggins’s phrase.
From my email exchange with Deadwyler, I took away that DARPA lost interest, and Deadwyler himself disappeared to go work for tobacco companies. And because orexin occurs naturally in the brain, it can’t be patented, which means that it’s hard to make money on it.
(I would expect a snortable cure for sleep would be worth something regardless, but I’m not a pharma company, so what do I know.)
Felt very different from modafinil; on a moda all-nighter I feel just mostly normal, kinda headachey, and a numbed fatigue. On orexin I still felt like I hadn’t slept; let me paste in my journal entry from that day (which is, to my great consternation, literally the only note which remains from this experiment).
“Feel spacey and out of it. More so than I did earlier, though that might just be that I’m interacting with people now.
Also hungry. More hungry than warranted? Not sure. Had a mealsquare around… 9? 10?
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Some people are willing to pay a premium for the ability to buy something legally.
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