The null model of science

Jonah Lehrer wrote about the (surprising?) power of publication bias.

http://​​m.newyorker.com/​​reporting/​​2010/​​12/​​13/​​101213fa_fact_lehrer?currentPage=all

Cosma Shalizi (I think) said something, or pointed to something, about the null model of science—what science would look like if there were no actual effects, just statistical anomalies that look good at first. I can’t find the reference, though.