3 years was the estimation of the expected effect by the main experimenter behind TAME - Nick Barzilai. This is what he expects to see. But I think more conservative will be to use Gwern’s estimation of 1 year, and I will turn to this estimate.
Theres is, in fact, another smaller trial of metformin for life extension called MILES, but it is not longitudinal study, just 3 weeks, but it has funding and preliminary FDA approval. Thus if TAME will happen, there will be two studies.
I am going to add the probability of success in the next version of the estimation and update the price of study (they told that they collected part of the money).
3 years was the estimation of the expected effect by the main experimenter behind TAME - Nick Barzilai. This is what he expects to see. But I think more conservative will be to use Gwern’s estimation of 1 year, and I will turn to this estimate.
Theres is, in fact, another smaller trial of metformin for life extension called MILES, but it is not longitudinal study, just 3 weeks, but it has funding and preliminary FDA approval. Thus if TAME will happen, there will be two studies.
I am going to add the probability of success in the next version of the estimation and update the price of study (they told that they collected part of the money).