Showing that many genes can be successfully and accurately edited in a live animal (ideally human). As far as I know, this hasn’t been done before! Only small edits have been demonstrated.
This is more or less our current plan.
Showing that editing embryos can result in increased intelligence. I don’t believe this has even been done in animals, let alone humans.
This has some separate technical challenges, and is also probably more taboo? The only reason that successfully editing embryos wouldn’t increase intelligence is that the variants being targeted weren’t actually causal for intelligence.
Gene editing to make people taller.
This seems harder, you’d need to somehow unfuse the growth plates.
on the other hand, “our patients increased 3 IQ points, we swear” is not as easily verifiable
A nice thing about IQ is that it’s actually really easy to measure. Noisier than measuring height, sure, but not terribly noisy.
They all also will make you rich, and they should all be easier than editing the brain. Why do rationalists always jump to the brain?
More intelligence enables progress on important, difficult problems, such as AI alignment.
This seems harder, you’d need to somehow unfuse the growth plates.
It’s hard, yes—I’d even say it’s impossible. But is it harder than the brain? The difference between growth plates and whatever is going on in the brain is that we understand growth plates and we do not understand the brain. You seem to have a prior of “we don’t understand it, therefore it should be possible, since we know of no barrier”. My prior is “we don’t understand it, so nothing will work and it’s totally hopeless”.
A nice thing about IQ is that it’s actually really easy to measure. Noisier than measuring height, sure, but not terribly noisy.
Actually, IQ test scores increase by a few points if you test again (called test-retest gains). Additionally, IQ varies substantially based on which IQ test you use. It is gonna be pretty hard to convince people you’ve increased your patients’ IQ by 3 points due to these factors—you’ll need a nice large sample with a proper control group in a double-blind study, and people will still have doubts.
More intelligence enables progress on important, difficult problems, such as AI alignment.
Lol. I mean, you’re not wrong with that precise statement, it just comes across as “the fountain of eternal youth will enable progress on important, difficult diplomatic and geopolitical situations”. Yes, this is true, but maybe see if you can beat botox at skin care before jumping to the fountain of youth. And there may be less fantastical solutions to your diplomatic issues. Also, finding the fountain of youth is likely to backfire and make your diplomatic situation worse. (To explain the metaphor: if you summon a few von Neumanns into existence tomorrow, I expect to die of AI sooner, on average, rather than later.)
This is more or less our current plan.
This has some separate technical challenges, and is also probably more taboo? The only reason that successfully editing embryos wouldn’t increase intelligence is that the variants being targeted weren’t actually causal for intelligence.
This seems harder, you’d need to somehow unfuse the growth plates.
A nice thing about IQ is that it’s actually really easy to measure. Noisier than measuring height, sure, but not terribly noisy.
More intelligence enables progress on important, difficult problems, such as AI alignment.
It’s hard, yes—I’d even say it’s impossible. But is it harder than the brain? The difference between growth plates and whatever is going on in the brain is that we understand growth plates and we do not understand the brain. You seem to have a prior of “we don’t understand it, therefore it should be possible, since we know of no barrier”. My prior is “we don’t understand it, so nothing will work and it’s totally hopeless”.
Actually, IQ test scores increase by a few points if you test again (called test-retest gains). Additionally, IQ varies substantially based on which IQ test you use. It is gonna be pretty hard to convince people you’ve increased your patients’ IQ by 3 points due to these factors—you’ll need a nice large sample with a proper control group in a double-blind study, and people will still have doubts.
Lol. I mean, you’re not wrong with that precise statement, it just comes across as “the fountain of eternal youth will enable progress on important, difficult diplomatic and geopolitical situations”. Yes, this is true, but maybe see if you can beat botox at skin care before jumping to the fountain of youth. And there may be less fantastical solutions to your diplomatic issues. Also, finding the fountain of youth is likely to backfire and make your diplomatic situation worse. (To explain the metaphor: if you summon a few von Neumanns into existence tomorrow, I expect to die of AI sooner, on average, rather than later.)