I do not have debilitating, world-shattering migraines. I just get headaches. More days than not. I have one right now. My mom once had a headache for an entire year. (This remains a medical mystery.) I have on occasion had headaches that lasted so long that I expected to imitate her, although so far I don’t think I’ve actually broken a full week (with breaks provided by ibuprofen).
I actually don’t usually medicate them. I do that when they are so bad that they wake me up in the middle of the night, or when they occur early in the day; otherwise I let sleep take care of them.
The one time I tried aspirin for pain relief, I don’t remember what it was for, although a headache was likely. I do remember that it gave me a stomachache which was worse than whatever it was supposed to get rid of for me. I wouldn’t expect a tiny dose to have this effect, especially if I took it with food or something, but if I were forced to rely on it as my only analgesic, I would be in something of a quandary.
The question is not, “Which do you dislike more: headaches, or cancer?” It’s, “Which do you prefer: effective pain relief for your extended, commonplace pain, or a risk-reducing drug which has not actually been extensively tested in your gender or age group?”
According to the U.S. Food and Drug Administration, “Ibuprofen can interfere with the antiplatelet effect of low-dose aspirin (81 mg per day), potentially rendering aspirin less effective when used for cardioprotection and stroke prevention.” Allowing sufficient time between doses of ibuprofen and immediate release aspirin can avoid this problem. The recommended elapsed time between a 400 mg dose of ibuprofen and a dose of aspirin depends on which is taken first. It would be 30 minutes or more for ibuprofen taken after immediate release aspirin, and 8 hours or more for ibuprofen taken before immediate release aspirin. However, this timing cannot be recommended for enteric-coated aspirin. But, if ibuprofen is taken only occasionally without the recommended timing, the reduction of the cardioprotection and stroke prevention of a daily aspirin regimen is minimal.[19]
Which of course doesn’t mention the cancer effects, but there you go.
My intuition suggests that regular low-dose aspirin and weekly ibuprofen still has benefits that outweigh the risks, as compared to weekly ibuprofen only. However, my intuition didn’t expect the effect, mentioned in the study’s full text, where alternate-day low-dose aspirin appeared to have no effect on cancer.
I do not have debilitating, world-shattering migraines. I just get headaches. More days than not. I have one right now. My mom once had a headache for an entire year. (This remains a medical mystery.) I have on occasion had headaches that lasted so long that I expected to imitate her, although so far I don’t think I’ve actually broken a full week (with breaks provided by ibuprofen).
Based solely on this description, this sounds like a pretty big deal. It also sounds like the sort of thing that might have a subtle but simple cause, which might be discovered by taking sufficiently detailed notes. I haven’t tried it myself, but I recall seeing references to software for this purpose, which might suggest specific things to investigate as possible causes. Are your headaches by any chance related (positively or negatively) to eating choline? Would you be able to detect if there were other relations of that type?
I tracked my headaches for about a month and a half once and then stopped, but I didn’t correlate it with food (particularly not choline, which I don’t even know what foods it comes in). I haven’t noticed any decisive correlations between various foods and the headaches. I got one yesterday evening (a rare overnighter, which I’m waiting for the ibuprofen to chase away now) and that day I had leftover vegetable strata and juice and toast with hummus and some ice cream, none of which are or contain unusual foods for me.
There’s lots of choline is in meat and eggs, and there’re smaller qantities of it in various other things. I’ve heard of headaches from both too much choline (when taking choline supplements) and too little (especially when taking piracetam, which depletes choline. I take both piracetam and choline citrate). Being a vegetarian is listed as a risk factor for deficiency on the wikipedia page.
That sounds like a worthwhile experiment. I would also suggest keeping a headache log and a food log (there are cell phone apps to make it easy; you photograph things instead of writing them down) and analyzing them after a month or two.
I’ll restart the headache log and combine the food diary. (Is it worth including times of eating various things?) A cell phone app will not help, since I don’t have a cell phone.
Or maybe just one that people don’t talk about much.
I only own a cell phone because I needed a way to have contact with the rest of the world while my internet access was down when I moved a few months ago. I don’t think it’s actually useable at this point—I haven’t added minutes to it for quite a while.
There’s also paracetamol (secret identity: acetaminophen (secret secret identity: tylenol)), which is not an NSAID, but I would guess you’ve tried it too. Fun snacks and/or facts:
Until 2010 paracetamol was believed to be safe in pregnancy (as it does not affect the closure of the fetal ductus arteriosus as other NSAIDs can.) However, in a study published in October 2010 it has been linked to infertility in the posterior adult life of the unborn.
recent research show some evidence that paracetamol can ease psychological pain
ETA: I just remembered two important contraindications: Don’t take more than 2g/day if you drink alcohol, and consider not taking more than 650mg at a time, since that’s the FDA’s revised recommendation after the old max dosage was shown to alter liver function in some healthy adults.
I do not have debilitating, world-shattering migraines. I just get headaches. More days than not. I have one right now. My mom once had a headache for an entire year. (This remains a medical mystery.) I have on occasion had headaches that lasted so long that I expected to imitate her, although so far I don’t think I’ve actually broken a full week (with breaks provided by ibuprofen).
I actually don’t usually medicate them. I do that when they are so bad that they wake me up in the middle of the night, or when they occur early in the day; otherwise I let sleep take care of them.
The one time I tried aspirin for pain relief, I don’t remember what it was for, although a headache was likely. I do remember that it gave me a stomachache which was worse than whatever it was supposed to get rid of for me. I wouldn’t expect a tiny dose to have this effect, especially if I took it with food or something, but if I were forced to rely on it as my only analgesic, I would be in something of a quandary.
The question is not, “Which do you dislike more: headaches, or cancer?” It’s, “Which do you prefer: effective pain relief for your extended, commonplace pain, or a risk-reducing drug which has not actually been extensively tested in your gender or age group?”
Fair enough—if I were in your shoes I would probably make the same decision as you.
All that said: is taking aspirin regularly and an ibuprofen once a week inferior to not taking aspirin regularly and an ibuprofen once a week?
I don’t know. Wikipedia says:
Which of course doesn’t mention the cancer effects, but there you go.
My intuition suggests that regular low-dose aspirin and weekly ibuprofen still has benefits that outweigh the risks, as compared to weekly ibuprofen only. However, my intuition didn’t expect the effect, mentioned in the study’s full text, where alternate-day low-dose aspirin appeared to have no effect on cancer.
Based solely on this description, this sounds like a pretty big deal. It also sounds like the sort of thing that might have a subtle but simple cause, which might be discovered by taking sufficiently detailed notes. I haven’t tried it myself, but I recall seeing references to software for this purpose, which might suggest specific things to investigate as possible causes. Are your headaches by any chance related (positively or negatively) to eating choline? Would you be able to detect if there were other relations of that type?
I tracked my headaches for about a month and a half once and then stopped, but I didn’t correlate it with food (particularly not choline, which I don’t even know what foods it comes in). I haven’t noticed any decisive correlations between various foods and the headaches. I got one yesterday evening (a rare overnighter, which I’m waiting for the ibuprofen to chase away now) and that day I had leftover vegetable strata and juice and toast with hummus and some ice cream, none of which are or contain unusual foods for me.
There’s lots of choline is in meat and eggs, and there’re smaller qantities of it in various other things. I’ve heard of headaches from both too much choline (when taking choline supplements) and too little (especially when taking piracetam, which depletes choline. I take both piracetam and choline citrate). Being a vegetarian is listed as a risk factor for deficiency on the wikipedia page.
I’ve been eating a lot of eggs lately. Should I try eating eggs every day for a week and then no eggs for a week and see what happens?
That sounds like a worthwhile experiment. I would also suggest keeping a headache log and a food log (there are cell phone apps to make it easy; you photograph things instead of writing them down) and analyzing them after a month or two.
I’ll restart the headache log and combine the food diary. (Is it worth including times of eating various things?) A cell phone app will not help, since I don’t have a cell phone.
Wow. That’s a rather significant divergence from culture! Tim Ferris would be impressed.
Or maybe just one that people don’t talk about much.
I only own a cell phone because I needed a way to have contact with the rest of the world while my internet access was down when I moved a few months ago. I don’t think it’s actually useable at this point—I haven’t added minutes to it for quite a while.
I had a cellphone once for about a week, but then I gave it back.
There’s also paracetamol (secret identity: acetaminophen (secret secret identity: tylenol)), which is not an NSAID, but I would guess you’ve tried it too. Fun snacks and/or facts:
http://en.wikipedia.org/wiki/Paracetamol
ETA: I just remembered two important contraindications: Don’t take more than 2g/day if you drink alcohol, and consider not taking more than 650mg at a time, since that’s the FDA’s revised recommendation after the old max dosage was shown to alter liver function in some healthy adults.
Tylenol works about as well as other non-ibuprofen analgesics, which is to say it makes the headaches fade rather than go the hell away.
I don’t drink alcohol ever, so that’s not an issue.