Phil, you’re a great author, and I don’t think that you need to be sorry for writing that fanfic. In case saying sorry satisfies some of your values, though, I accept your apology on behalf of Fluttershy from FiM.
I was previously aware that e.g. thinking of yourself as a pony who trys new things makes you more likely to try new things in the future, though reading your story helped me grasp that on a deeper, more emotional level than I had before. In fact, I think that by choosing “Fluttershy” as my username on LessWrong, I inadvertently nudged myself to eventually become both kinder and more shy than I would have become if I had chosen a different username.
Note to the FiMFiction crowd: I’ve made an account here.
I was kidding. I found it very funny to see a politely-written article by Fluttershy about castrating males.
I’m not interested in castration itself for life-extension. I wouldn’t do it, I’m too old anyway, and I wouldn’t do it to anybody else, particularly not a 10-year old. Besides, somebody who’s 10 years old today will probably live into the 22nd century, and they’ll come up with something better than castration.
It is interesting if it causes life-extension. We’d like to know how it does. But I suspect we already do.
There are 2 large, opposing pathways in every cell of every multicellular animal and more things besides, from yeast all the way to humans, the TOR and FOXO pathways. TOR stands for Target Of Rapamycin. It’s the thing rapamycin inhibits. FOXO stands for Forkhead box class O. A forkhead box is a transcription gene, one that, when transcribed, causes other genes to be (or not be) transcribed.
mTOR causes growth, cell proliferation, stem cell differentiation, cell cycle promotion, muscle growth, bone growth, wound healing. It also increases DNA damage, diabetes, cancer, and just about every other major cause of aging.
FOXO up-regulation causes DNA repair, restoration of insulin response, apoptosis (cancer suppression), mitochondrial biogenesis, and a wide variety of cell protectant effects.
Every known mechanism of life-extension activates FOXO and suppresses TOR. Rapamycin, resveratrol, caloric restriction, exercise, nearly every genetic mutation that extends life, and, yes, castration.
Fluttershy:
I’m really sorry about that fanfic, okay?
Phil, you’re a great author, and I don’t think that you need to be sorry for writing that fanfic. In case saying sorry satisfies some of your values, though, I accept your apology on behalf of Fluttershy from FiM.
I was previously aware that e.g. thinking of yourself as a pony who trys new things makes you more likely to try new things in the future, though reading your story helped me grasp that on a deeper, more emotional level than I had before. In fact, I think that by choosing “Fluttershy” as my username on LessWrong, I inadvertently nudged myself to eventually become both kinder and more shy than I would have become if I had chosen a different username.
Note to the FiMFiction crowd: I’ve made an account here.
I was kidding. I found it very funny to see a politely-written article by Fluttershy about castrating males.
I’m not interested in castration itself for life-extension. I wouldn’t do it, I’m too old anyway, and I wouldn’t do it to anybody else, particularly not a 10-year old. Besides, somebody who’s 10 years old today will probably live into the 22nd century, and they’ll come up with something better than castration.
It is interesting if it causes life-extension. We’d like to know how it does. But I suspect we already do.
There are 2 large, opposing pathways in every cell of every multicellular animal and more things besides, from yeast all the way to humans, the TOR and FOXO pathways. TOR stands for Target Of Rapamycin. It’s the thing rapamycin inhibits. FOXO stands for Forkhead box class O. A forkhead box is a transcription gene, one that, when transcribed, causes other genes to be (or not be) transcribed.
mTOR causes growth, cell proliferation, stem cell differentiation, cell cycle promotion, muscle growth, bone growth, wound healing. It also increases DNA damage, diabetes, cancer, and just about every other major cause of aging.
FOXO up-regulation causes DNA repair, restoration of insulin response, apoptosis (cancer suppression), mitochondrial biogenesis, and a wide variety of cell protectant effects.
Every known mechanism of life-extension activates FOXO and suppresses TOR. Rapamycin, resveratrol, caloric restriction, exercise, nearly every genetic mutation that extends life, and, yes, castration.
So it’s probably better to take rapamycin.