I was kidding. I found it very funny to see a politely-written article by Fluttershy about castrating males.
I’m not interested in castration itself for life-extension. I wouldn’t do it, I’m too old anyway, and I wouldn’t do it to anybody else, particularly not a 10-year old. Besides, somebody who’s 10 years old today will probably live into the 22nd century, and they’ll come up with something better than castration.
It is interesting if it causes life-extension. We’d like to know how it does. But I suspect we already do.
There are 2 large, opposing pathways in every cell of every multicellular animal and more things besides, from yeast all the way to humans, the TOR and FOXO pathways. TOR stands for Target Of Rapamycin. It’s the thing rapamycin inhibits. FOXO stands for Forkhead box class O. A forkhead box is a transcription gene, one that, when transcribed, causes other genes to be (or not be) transcribed.
mTOR causes growth, cell proliferation, stem cell differentiation, cell cycle promotion, muscle growth, bone growth, wound healing. It also increases DNA damage, diabetes, cancer, and just about every other major cause of aging.
FOXO up-regulation causes DNA repair, restoration of insulin response, apoptosis (cancer suppression), mitochondrial biogenesis, and a wide variety of cell protectant effects.
Every known mechanism of life-extension activates FOXO and suppresses TOR. Rapamycin, resveratrol, caloric restriction, exercise, nearly every genetic mutation that extends life, and, yes, castration.
I was kidding. I found it very funny to see a politely-written article by Fluttershy about castrating males.
I’m not interested in castration itself for life-extension. I wouldn’t do it, I’m too old anyway, and I wouldn’t do it to anybody else, particularly not a 10-year old. Besides, somebody who’s 10 years old today will probably live into the 22nd century, and they’ll come up with something better than castration.
It is interesting if it causes life-extension. We’d like to know how it does. But I suspect we already do.
There are 2 large, opposing pathways in every cell of every multicellular animal and more things besides, from yeast all the way to humans, the TOR and FOXO pathways. TOR stands for Target Of Rapamycin. It’s the thing rapamycin inhibits. FOXO stands for Forkhead box class O. A forkhead box is a transcription gene, one that, when transcribed, causes other genes to be (or not be) transcribed.
mTOR causes growth, cell proliferation, stem cell differentiation, cell cycle promotion, muscle growth, bone growth, wound healing. It also increases DNA damage, diabetes, cancer, and just about every other major cause of aging.
FOXO up-regulation causes DNA repair, restoration of insulin response, apoptosis (cancer suppression), mitochondrial biogenesis, and a wide variety of cell protectant effects.
Every known mechanism of life-extension activates FOXO and suppresses TOR. Rapamycin, resveratrol, caloric restriction, exercise, nearly every genetic mutation that extends life, and, yes, castration.
So it’s probably better to take rapamycin.