A while back, I was driving to a friend’s house every few months to hang out.
The first time, of course, I used a GPS to direct me there. Had this happened in the early 2000s, I would have printed out Google Maps turn-by-turn directions.
After a few times, I tried not using the GPS to direct me there, although I screwed up the final turns a bit and might have turned on the GPS to direct me around the twisty maze of curved streets and cul-de-sacs.
I wouldn’t have done that kind of thing if I had an appointment that I didn’t want to be late to.
Also, using a GPS insulates you a bit from surprise traffic/blockages that you might not know about beforehand — it can either just not direct you that way in the first place, or it can suggest an alternate route.
To answer your question more directly:
In almost all cases, I don’t care enough about the random patch of land on the way to and around my destination to build up a mental map of it before setting out.