I’m not sure if they’ve been tested, but other anxiety meds (Duloxetine especially) have been. In the short run though, I wouldn’t expect benzos to work much better than having a relaxed day in a good mood. It seems to take more time or at least some deeper changes in order to reduce the pain a lot.
Neuroplastic pain involves established neural circuits that persist even when anxiety is temporarily reduced. These pathways form over time and need retraining to resolve. It seems similar to how established habits don’t disappear after one relaxed day for people who have compulsive habits due to anxiety.
I suppose an 80⁄20 version would be to just load some books and resources into an LLM’s context and tell it to be a good therapist who implements this stuff. I haven’t tried this myself though, and without the context I think Claude got some things wrong when it tried to recommend me exercises to do.