Bryan Johnson is getting a ton of data on biomarkers, but N=1.
How hard would it be to set up a smart home-test kit, which automatically uploads your biomarker data to an open-source database of health?
Combining that with food and exercise journaling, and we could start to get some crazy amounts of high resolution data on health
Getting health companies to offer discounts for people doing this religiously could create a virtuous cycle of more people putting up results, getting better results and therefore more people signing up for health services
Runescape would be a good one