There is lots of interesting thinking in the tools for thought space that intersect with your idea.
A few people with interesting, thoughtful ideas;
Michael Nielsen: https://michaelnielsen.org—eg, https://numinous.productions/ttft/
Andy Matuschak: https://andymatuschak.org—eg, https://notes.andymatuschak.org/zJrfPCbY7GcpV9asEc8NTVzXTAV4TvRFMuY6
Linus: https://thesephist.com—https://thesephist.com/posts/materials/
It always seemed as though a lot of Bill Gates’s philanthropy broadly followed EA principles. But his foundation and, eg, efforts to eradicate malaria precede this timeline.