One is not philosophically obliged to regard the nature of reality as ineffable or inescapably uncertain.
Quarks are a good place to explore this point. The human race once had no concept of quarks. Now it does. You say that inevitably, one day, we’ll have some other concept. Maybe we will. But why is that inevitable? Why can’t quarks just turn out to be part of how reality actually is?
You cite Nagarjuna and talk about emptiness, so that gives me some idea of where you are coming from. This is a philosophy which emphasizes the role of concepts in constituting experience, and the role of the mind in constituting concepts, and typically concludes that reality has no essence, no nature that can be affirmed, because all such affirmations involve concepts that are introduced by the mind, rather than being inherent to anything.
This conclusion I think is overreaching. I actually consider direct experience to be the ultimate proof that reality is not just formlessness carved by mind. Consciousness is not just raw being, it is filled with form. My words and concepts may not capture it properly, I may not even notice everything that is implied by what I see or what I am. But I do see that complexity and multiplicity are there in reality—at the very least, they are there in my own consciousness.
Non-attachment to theories and concepts is a good thing if you’re interested in truth, and know that you don’t know the truth. It also has some pragmatic value if reality changes around you and you need to adapt. But in fundamental matters, one does not have to regard every concept and hypothesis that we have, as necessarily temporary. In some of them we may have latched onto the actual objective truth.
P.S. Having criticized the philosophy of emptiness, let me add ironically that just a few hours ago, I investigated a proposal for AI alignment that someone had posted here a few months ago, and found it to be very good—and its model of the mind, a nondual viewpoint is the highest form. So your philosophy may actually put you in a good position to appreciate the nuances of this potentially important work.
“This prompt (sometimes) makes ChatGPT think about terrorist organisations”