With regards to animal experimentation before first upload and so on, a running upload is nothing but fancy processing of a scan of, likely, a cadaver brain, legally no different from displaying that brain on computer, and doesn’t require any sort of FDA style stringent functionality testing on animals, not that such testing would help for a brain much bigger, with different neuron sizes, and with the failure modes that are highly non-obvious in animals. Nor that such regulation is even necessary, as the scanned upload of dead person, functional enough to recognize his family, is a definite improvement over being completely dead, and to prevent it equates mercy killing accident victims who have good prospect at full recovery, to avoid the mere discomfort of being sick.
The gradual progress on humans is pretty much a certainty, if one is to drop the wide eyed optimism bias. There are enough people who would bite the bullet, and it is not human experimentation—it is mere data processing—it might become human experimentation decades after functional uploads.
Legally, a mind upload is only different from any other medical scan in mere quantity, and a simulation of brain is only qualitatively different from any other processing. Just as the cryopreservation is only a form of burial.
Furthermore, while it would seem to be better to magically have the mind uploading completely figured out without any experimentation on human mind uploads, we aren’t writing a science fiction/fantasy story, we are actually building the damn thing in the real world where things tend to go wrong.
edit: also, a rather strong point can be made that it is more ethical to experiment on a copy of yourself than on a copy of your cat or any other not completely stupid mammal. The consent matters.