A brilliant post with many links to the Yudkowsky Canon. It has just become a bookmark.
One quip: the study which revealed that a majority of research findings were false seemed to rely on a simulation, and on one meta-study performed earlier by the group. Have I understood this correctly?
Perhaps the p for biological experiments should be lower, but my first inclination is to defend the field I work in and its custom of p<0.05 .
Every time I open up an animal for surgery, the animals nerves are lying in slightly different places. There is a different amount of muscle-tissue obscuring the nerve I have to record from. I have to re-manufacture my electrode after every few surgeries. The hook on my electrode is differently shaped each time. When I put the nerve on the electrode, I pull it up with a different amount of force, in a different position, and do a different degree of damage to the nerve’s processes.
Every animal is slightly different, and every surgery goes slightly differently.
Therefore, I think it might be understandable, why I need a p that is higher than a physicists, because if the physicist uses the same stock of materials, he has much less variability in his setup to begin with.
James Bach,
I am enjoying the online draft of your book very much, thank you for posting this!