Would also love your thoughts on this one I posted a while back if convenient—not sure if I’m thinking about this one correctly or not: https://www.lesswrong.com/posts/GoBBmmKzvT8XFwE8g/do-nasal-decongestants-increase-risk-associated-with
Dorikka
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Thanks for this, super helpful! Is NAC something to start taking when feeling symptomatic or something to start taking way ahead of time (like vitamin D)? Re indomethacin, it sounds like this is something that it would be worth getting a prescription of when feeling symptomatic (assuming it’s not a controlled substance or something similarly difficult for a doctor to prescribe) - wanted to feedback this to you to make sure I’m understanding correctly.
[Question] What is the current state of knowledge around COVID-19 at-home remedies?
[Question] Do nasal decongestants increase risk associated with cardiovascular (and respiratory via second-order effects) symptoms from COVID-19?
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Thanks. I haven’t used liquid products much before. Anything you’ve noticed that’s significantly different in terms of onset time, effect duration, etc?
Anyone know where I can find melatonin tablets <300 mcg? Splitting 300 mcg into 75 mcg quarters still gives me morning sleepiness, thinking smaller dose will reduce remaining melatonin upon wake time. Thanks.
Surely, as rationalists, we should
So awkward it hurts that this is even a thing.
Thanks for noting this.
Aren’t new open threads usually posted on Mondays? Today is the 27th, not 28th.
404: Generalized model not found
Any particular evidence in favor of this approach, anecdotal or otherwise?
Seem to be implying that you are more likely to be in a simulation if historixcally impt. Interesting
No other source, but keep in mind that helmets are tuned for a certain force level. Too durable and helmet does not reduce peak force as it does not crush. Too weak and it crushes quickly, again with little reduction in peak force. This should just empasize to use the 25% number here though since the forces are more representative.
Redacting “won’t do much of anything” except as implied by 25%, but keep in mind that if peak accelerations are much higher than the given case, the helmet will be less effective due to the above. This may or may not be the case in car crashes depending on speed.
Interesting—thanks for checking this. If the Severity Index is claiming no significant damage below 1200, I think it may be incorrect or may have a different criterion for severe damage. Some helmet standards seem to be fairly insensitive, only accounting for moderate or severe brain injury whereas MTBI can have long lasting effects. Yes, I discount Severity claims as the metric does not appear to give reasonable results. 188g is a crapload of linear acceleration, but metric puts it under threshold...I dont buy it, so am left to judge on peak linear accel instead (shame that rotational accel was not measured...)
The data is posted above, unlikely to get around to Dropboxing it so I can link (as it was from an email). I agree with you re body movement in a vehicle collision. However, at some point your body would stop. If your head hit something while your body was in motion, thr impacted object would likely have enough strength to bring the head to an abrupt halt. (Contrast with a knife being punched through paper mache—I would expect the force on the lnofe to be much lower than if hitting concrete, as it would go through the paper mache without much velocity change.)
I am curious about your terminal goal here.
shrug The pdf for sincerity looks bimodal to me.
This is the most tantalizing thread on the page.
Thanks Zvi, these are super informative!
Use of povidone-iodine as mouthwash and nasal spray looks promising as prophylaxis (and potentially treatment, but lower confidence on that.) The study Zvi linked (https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2770785#ooi200049r25) appears to be the latest in discussions occurring in otolaryngology since April (https://www.google.com/search?q=povidone+iodine+nasal+spray&oq=pobidone&aqs=chrome.1.69i57j35i39l2j0l2.2542j0j4&client=ms-android-att-us&sourceid=chrome-mobile&ie=UTF-8). Other informative articles here (https://journals.sagepub.com/doi/full/10.1177/0145561320932318) and (https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3563092).
I plan to start using appropriately diluted povidone iodine solution as nasal spray and mouthwash when I’m in contact with (or proximity to) strangers. I’m pretty comfortable using Betadine 10% as the base for mouthwash (diluting it with water since the commercially sold mouthwash version is somewhat difficult to procure.)
I’d love any insights/thoughts on the correct product to use as the base for nasal spray (prior to mixing with saline), as the above protocol does not reference a particular product, and the additives in different povidone-iodine solutions seem to vary a fair amount.