Thanks for this, super helpful! Is NAC something to start taking when feeling symptomatic or something to start taking way ahead of time (like vitamin D)? Re indomethacin, it sounds like this is something that it would be worth getting a prescription of when feeling symptomatic (assuming it’s not a controlled substance or something similarly difficult for a doctor to prescribe) - wanted to feedback this to you to make sure I’m understanding correctly.
You can take NAC every day, it’s basically an amino acid and acetate joined together in a peptide bond. Some people do take it every day. I would be hesitant taking it for very long times, since there are a few mouse studies in which mice that got a high dose constantly had higher cancer risks, but mice and cancer are a weird combo already and may not be representative. I would up the dose when actively sick.
Indomethacin is a 1960s NSAID that is used less these days because there are slightly safer NSAIDs for most indications—it has several times the rate of causing ulcers compared to advil for example, but I think that’s mostly for chronic use rather than short term. They recommend you take it with an antacid, so I would definitely take it with… famotidine, a drug that blocks histamine receptors involved both in stomach acid production AND possibly involved in the inappropriate inflammation that COVID is causing, and which was associated with higher recoveries in some studies. These days I think indomethacin it is mostly used for gout, some types of arthritis, migraines, and some edge cases like helping premature babies rewire their hearts for breathing instead of using a placenta. It’s DEFINITELY something you would only take while actively sick, 5-10 days. It’s prescription-only in the US, but not exactly ‘controlled’, it’s not like anybody takes it for fun.
Thanks for this, super helpful! Is NAC something to start taking when feeling symptomatic or something to start taking way ahead of time (like vitamin D)? Re indomethacin, it sounds like this is something that it would be worth getting a prescription of when feeling symptomatic (assuming it’s not a controlled substance or something similarly difficult for a doctor to prescribe) - wanted to feedback this to you to make sure I’m understanding correctly.
You can take NAC every day, it’s basically an amino acid and acetate joined together in a peptide bond. Some people do take it every day. I would be hesitant taking it for very long times, since there are a few mouse studies in which mice that got a high dose constantly had higher cancer risks, but mice and cancer are a weird combo already and may not be representative. I would up the dose when actively sick.
Indomethacin is a 1960s NSAID that is used less these days because there are slightly safer NSAIDs for most indications—it has several times the rate of causing ulcers compared to advil for example, but I think that’s mostly for chronic use rather than short term. They recommend you take it with an antacid, so I would definitely take it with… famotidine, a drug that blocks histamine receptors involved both in stomach acid production AND possibly involved in the inappropriate inflammation that COVID is causing, and which was associated with higher recoveries in some studies. These days I think indomethacin it is mostly used for gout, some types of arthritis, migraines, and some edge cases like helping premature babies rewire their hearts for breathing instead of using a placenta. It’s DEFINITELY something you would only take while actively sick, 5-10 days. It’s prescription-only in the US, but not exactly ‘controlled’, it’s not like anybody takes it for fun.
Apparently I am still consistently a month or two ahead of the curve.
https://www.sciencedirect.com/science/article/pii/S0306987720314973
https://www.sciencedirect.com/science/article/pii/S1521661620306513