I think it’s still important to note that “not giving up” can lead not just to lack of success, but also to value destruction (Pets.com; Theranos; WeWork).
If you’re going to interpret the original “don’t give up” advice so literally and blindly that “no matter what the challenges are I’m going to figure them out” includes committing massive fraud, then yes, it will be bad advice for you. That’s a really remarkably uncharitable interpretation.
Oops—I forgot that this was going to be auto-crossposted to LW and probably would have prevented that if I remembered, since it’s weirdly meta (it was intended mostly as a placeholder for people visiting my website and wondering why there were no recent posts). I guess I’ll leave it here now since it got a lot more upvotes than I expected though :)