A lot of chemo drugs are toxic, aren’t they? I’m actually not sure how they were located as hypotheses. Does anyone have info on this?
This is discussed to some extent in Siddhartha Mukherjee’s “The Emperor of All Maladies” which is an excellent book about the history of cancer. In most cases, chemo drugs are chosen because they target a specific phenomenon that is occurring in cancer cells more commonly than it is occurring in other cells. The most common example is mitosis (since the main problem with cancer cells is that they just keep growing). This is why chemo drugs often harm cell types like immune cells and hair follicles- these cells are some of the few cells in the body that are often growing.
A historical example may be instructive. One of the first attempts at chemo was for leukemia. It was known that leukemia cells had strange mitosis behavior and distorted nuclei. So researchers tried giving folic acid to the patients since this was known to be important in cell dvision. Unfortunately, this made the leukemia even more virulent: it turned out that levels of folic acid were actually a limiting factor on how fast the cancer cells could divide. So then they tried giving them chemicals that interfered with the metabolism and processing of folic acid. This was the first set of chemo drugs that had any success (although it turned out to be always temporary: the cancer almost inevitably evolved around it).
This is discussed to some extent in Siddhartha Mukherjee’s “The Emperor of All Maladies” which is an excellent book about the history of cancer. In most cases, chemo drugs are chosen because they target a specific phenomenon that is occurring in cancer cells more commonly than it is occurring in other cells. The most common example is mitosis (since the main problem with cancer cells is that they just keep growing). This is why chemo drugs often harm cell types like immune cells and hair follicles- these cells are some of the few cells in the body that are often growing.
A historical example may be instructive. One of the first attempts at chemo was for leukemia. It was known that leukemia cells had strange mitosis behavior and distorted nuclei. So researchers tried giving folic acid to the patients since this was known to be important in cell dvision. Unfortunately, this made the leukemia even more virulent: it turned out that levels of folic acid were actually a limiting factor on how fast the cancer cells could divide. So then they tried giving them chemicals that interfered with the metabolism and processing of folic acid. This was the first set of chemo drugs that had any success (although it turned out to be always temporary: the cancer almost inevitably evolved around it).
That’s really interesting, thanks!