Any model/hypothesis which explains our observations as very rare events is intrinsically less likely than other models that explain our observations as typical events.
This is true for all cases where the observer is not noticeably entangled in a causal manner with the event they are trying to observe. Otherwise, the Observation Selection Effect can contribute false evidence. If we presumed that earth is typical, then there should also be life on Mars, and in most other solar systems. However, we wouldn’t ever have asked the question if we hadn’t evolved into intelligent life. The same thing that caused us to ask the question also caused the one blue-green data point that we have.
To illustrate: If you came across an island in the middle of the ocean, you might do well to speculate that such islands must be extremely common for you to come across one in the middle of the ocean. However, if you see smoke rising from beyond the horizon, and sail for days until finally reaching a volcanic island, you could not assign the same density to such volcanic islands as to ordinary islands. The same thing that caused you to observe the volcanic island also caused you to search for it in the first place. In the case of observable life, the Observation Selection Effect is much, much stronger because there’s no way we could conceivably have asked the question if we hadn’t come into existence somehow. P(life is common|life on earth)=P(life is common), because knowing that life did evolve on earth can’t give us Bayesian evidence for or against the hypothesis that life is common.
Observational Selection Effects due to the Simulation Argument
Some physical universes tend to produce tons of simulated universes containing observers such as ourselves.
This changes things, potentially. Everything I’ve said in previous posts has been conditional on the assumption that we don’t live in a simulation. If we do, it is likely that our universe roughly resembles the real universe in some aspects. Perhaps they are running a precise simulation based on reality, or perhaps they are running a simulation based on a small change to reality, as an experiment. However, the motives of such a civilization are difficult to predict with any accuracy, so I suspect that the vast majority of possible hypotheses are things we haven’t even thought of yet. (unknown unknowns.) So, although your specific hypothesis becomes more likely if we are in a simulation, so do all other possible hypotheses predicting large numbers of simulations.
Now on to the potential early filter stages:
(2) Oops. I should have specified huge amounts of liquid water in the inner solar system. Mars has icecaps, and some of Jupiter’s moons are ice-balls, possibly with a liquid center. Earth has rather a lot of water, despite being well inside the frost line. When the planets were forming from an accretion disc, the material close to the sun would have caused any available water to evaporate, for the same reason there isn’t much water on the moon (at least outside a couple craters on the poles, which are in continuous shadow). Far enough out, though, and the sun’s heat is disperse enough that ice is stable; hence the icy moons of Jupiter. The best hypothesis we have is that some mechanism transported a large amount of water to Earth after it formed, perhaps via comets or asteroids. It just occurred to me that this might have been during the late heavy bombardment, or it might be just another coincidence. As you point out regarding our large moon, complex systems can be expected to have many, many 1-in-100 coincidences, simply because of statistics.
(3) Panspermia / Abiogenesis: it sounds like “Life Before Earth” isn’t a mainstream consensus, based on a couple comments below. I do know, however, that mainstream biology does teach Panspermia alongside Abiogenesis, so neither of them appears to be a clear winner by merit of scientific evidence. I’m not even sure of how to practically estimate their respective complexities, in order to use Occam’s Razor or Solomonoff Complexity to posit a reasonable prior. It would be nice to bound the problem enough to estimate the probabilities of both with sufficient accuracy to determine which is more likely. Until then though, I guess we’ll have to leave it at 50/50%.
Also, there’s a weird coincidence where the formation of the first life on earth seems to coincide well with the end of the late heavy bombardment,
That’s only a weird coincidence if one assumes abiogenesis on earth. Panspermia explains that ‘coincidence’ perfectly.
The late heavy bombardment coinciding with the start of life is only explained by panspermia if (1) the rocks came from outside the solar system, which is unlikely given the huge amount of material, or (2) the rocks brought life from another source within our own solar system. This could also be explained if life required the large influx of matter/energy/climate disturbance/heating or whatever, or if life was continuously wiped out by the harsh environment until it finally started flourishing when it ended.
(8) Good point about extinction events being an evolutionary catalyst. Aside from possibly generating the primordial soup for Abiogenesis, snowball earths may have catalyzed early advancements, and mammals wouldn’t have been able to supersede dinosaurs without a certain meteor.
(9) Perhaps “abstract thought” isn’t the perfect term to use, since it is common enough to have become vague instead of precise. The stress should be on the word “abstract”, not on the word “thought”. Chimps and many other animals do have simple language, although no complex grammar structures. They can’t abstract an arbitrary series of motions necessary to make or use a tool into language, and communicate it without showing it. Abstract language is most of what I’m referring to, but not all of it.
Language leads to technology which quickly leads to civilization and planetary dominance. It is a winner take all effect.
This is likely why neanderthals went extinct, although we coexisted for quite a while. It still doesn’t explain why there aren’t octopus civilizations, since we haven’t changed that environment much until extremely recently. We haven’t evolved noticeably in hundreds of thousands of years, but haven’t colonized the planet until the last ~16,000 years. If our colonization is the only thing holding back other potential intelligent life, we’d expect to see elephants and parrots at least at the stone tool or fire level of technology. Why don’t octopus hunt with spears or lobster traps?
I skipped over a lot of your good points, largely because I see them as correct. I sill don’t buy the argument that life is common though, although I’d be less confident in any such assertion in either direction if we were in a simulation, just because of the huge amount of uncertainty that adds to things.
The origin of life on earth being coincident with the end of the late heavy bombardment could entirely be an artifact of the fact that no rock from before that time survives to this day. It could well be older on Earth. The reworking of the crust was not complete at any given time, it took hundreds of megayears and at any given time most of the crust would be undisturbed.
Water in the inner system has the complication of the fact that not only do you need to get water, you need to hold onto water. Small objects will not hold onto light molecules out of sheer gravity issues. Mars is not holding onto water or other atmospheric gases well at all because of both gravitational issues, and solar radiation sputtering the upper atmosphere off into space. Venus has all the gravity it could need, but A—no geomagnetic field (at least at this point in its history) and B—got so hot that all the water went into the atmosphere, where it gets cracked by radiation in the upper atmosphere and the hydrogen leaves (allowing the oxygen to react with volcanic gases giving you sulfuric acid and phosphoric acid and the like). The same process happens on Earth but the pool of atmospheric water is SO MUCH SMALLER due to all the liquid volume and the fact that we have this lovely temperature trap in our atmosphere that makes it condense out before it gets too high up that the rate is extremely small.
I would say the only time you can call humans ‘dominant’ is after the widespread adoption of agriculture, which was much more gradual than many people think—people were probably propagating seedless figs 20k years ago and much longer ago were altering the composition of plants and animals in various biomes just via their actions. Since agriculture got big we have become ecosystem engineers in the vein of bears, but rather larger in our effects. We have been creating new large-scale-symbiotic biomes where plants and animals flow matter and energy into each other and where we take care of dispersal rather than the plants themselves doing as much of it, for example. That’s the unique aspect of humanity. Since then we have also started breaking into non-biological forms of energy—raw sunlight, water flow, the black rocks that are basically 500 megayears of stored sunlight—and have been using those for our purposes too in addition to the biological energy flow that all other biomes deal with.
It will be very interesting to see how human ecology continues to change after the extremely concentrated energy sources that represent most of the power we have used over the last 200 years go away. The end result might be very big but might not have the sheer flux of inefficient extractive growth—think weeds colonizing a freshly plowed field, versus an old-growth forest.
That is a very interesting question and one which there’s constant research going into.
A few initial points. First, its becoming clearer and clearer that ‘prokaryotes’ is a very poor grouping to use for much of anything. The bacteria most of us think of are the smaller, faster-replicating members of the eubacteria. There’s also the archaebacteria, which are deeply and fundamentally different from the eubacteria in their membrane composition, cell wall structure, DNA organization, and transcription machinery.
Second, it’s becoming more and more clear that the eukaryotes are indeed the result of an early union of eubacteria and archaebacteria. I saw some very cool research at a conference last December bolstering the “eocyte hypothesis”—the idea that the Eukaryotic nuclear genome roots in one particular spot of the archaebacterial tree plus loads of horizontal gene transfer from the eubacteria that became the mitochondria. You can’t root it there just by aligning things, this was long enough ago that base sequence is effectively randomized, you need to look at what sorts of proteins exist, characters that change very rarely as opposed to mere sequence, and its a very hard question that has required a LOT of sequence data from a LOT of organisms. Most of our DNA structure and transcription and some of our protein processing looks like the archaebacteria, but basically all of our metabolism looks like the eubacteria. This is interesting in the light of recent discoveries of symbiotic pairings of archaebacteria and eubacteria in nature in which they exchange metabolic products.
Anyways, the eubacteria and archaebacteria have deeply different transcription machinery and make their membranes in fundamentally different ways. Central carbon metabolism is all but identical though as is a lot of other pathways, and the core biochemistry. I’ve seen work proposing that the eubacteria and archaebacteria may have diverged before living things managed to synthesize their own membrane components rather than scavenging them from the environment. I’ve also seen interesting work to the effect that certain clay minerals can assemble fatty acids and other such membrane-building substances from acetate under the proper energetic conditions.
There’s also a lot of diverstiy in DNA and RNA processing methods that isn’t in any of the cellular life – there are truly bizarre ways of doing this that you only find in viruses. Viruses mutate incredibly rapidly and so you cannot try to root them anywhere, they change too fast. That being said there are proposals that they may be primordial, elements of the very wide range of possible nucleic acid processing mechanisms that existed before the current forms of cellular life really were established and took off. The eubacterial and archaebacterial models may have taken off with remnants of the rest winding up parasitizing them.
Rampant horizontal transfer of genes, especially early when cell identity might not have been so strong, makes all this very complicated.
There’s a school of thought in origin of life research that autocatalytic metabolism was important, and another that replicating polymers were important. The former posits that metal-ion driven cyclical reactions like the citric acid cycle can take off and take over, and wind up producing lots of interesting chemical byproducts that can then capture it and become discrete self-replicating units. The latter points out that elongating polymers in membrane bubbles speed the growth and splitting of these bubbles. They’re both probably important. It should be noted too that these ideas intersect – one of the popular metabolic ideas, polyphosphate, is actually represented in our nucleic acids. Polyphosphate is an interesting substance that can be built up by the right chemial reactions, and can drive other ones when it breaks down. Every ATP, GTP, etc is a nice chemical handle on the end of a chain of three phosphates – a short polyphosphate. By breaking down those polyphosphates you build polymers.
Proteins obviously came very early and gave a huge advantage, and the genetic code is damn near universal with all deviations from the standard one obvioulsy coming in after the fact. Whatever could make proteins probably took over quickly. The initial frenzy, whatever it was, probably eventually lead to a diverse population of compartments processing their nucleic acids in diverse ways and sending pieces of their codes back and forth, which eventually gained advantages by building their own membranes, and eventually cell walls, in different ways. Some of these populations probably took off like mad, making the eubacteria and archaebacteria, and others remained only as horizontally transferred elements like viruses or transposons or the like.
Written in a hurry, may be edited or clarified/extended later.
A clade of archaebacteria found via metagenomics at an undersea vent (uncultured). Contains huge numbers of eukaryotic characteristic genes that are important for formerly eukaryotic specific functions. The eukaryotes cluster within this clade rather than as a sister clade.
P(life is common|life on earth)=P(life is common), because knowing that life did evolve on earth can’t give us Bayesian evidence for or against the hypothesis that life is common.
That math is rather obviously wrong. You are so close here—just use Bayes.
We have 2 mutually exclusive models: life is common, and life is rare. To be more specific, lets say that the life is common theory posits that life is a 1 in 10 event, the life is rare theory posits that life is a 1 in a billion event.
Let’s say that our priors are P(life is common) = 0.09, and P(life is rare) = 0.91
Now, our observation history over this solar system tells us that life evolved on earth—and probably only complex life on earth, although there may be simple life on mars or some of the watery moons.
As we are just comparing two models, we can compare likelihoods
P(life is common | life on earth) ]= P(life on earth | life is common) P(life is common) = 0.09 * 0.1 = 0.009 ~ 10^-2
P(life is rare | life on earth) ]= P(life on earth | life is rare) P(life is rare) = 10^-9 * 0.91 ~ 10^-9
To convert to actual probabilities we would need to divide by P(life on earth), but that doesn’t really matter because it is a constant normalizing factor.
However, the motives of such a civilization are difficult to predict with any accuracy, so I suspect that the vast majority of possible hypotheses are things we haven’t even thought of yet. (unknown unknowns.) So, although your specific hypothesis becomes more likely if we are in a simulation, so do all other possible hypotheses predicting large numbers of simulations.
I agree with your general analysis here, although it is important to remember that the full hypothesis space is always infinite. For tractable inference, we focus on a small subset of the most promising theories/models.
When considering the wide space of potential simulators, we must focus on key abstractions. For example, we can focus on models in which advanced civs have convergent instrumental reasons for creating large numbers of simulations. I am currently aware of a couple of wide classes of models that predict lots of sims. Besides aliens simulating other aliens, our descendants could have strong motivations to simulate us—as a form of resurrection for example, in addition to the common motivator for improving world models. There is also the possibility of creating new artificial universes, in which case there may be interesting strong motivators to create lots of universes and lots of simulations as a precursor step.
(3) Panspermia / Abiogenesis: it sounds like “Life Before Earth” isn’t a mainstream consensus, based on a couple comments below.
No—that paper is not even really mainstream. I mentioned it as an example of the panspermia model and the resulting potentially expanded timeframe for the history of life. If life is really that old, then it becomes less likely that a single early elder civ colonized the galaxy early and dominated.
P(life is common|life on earth)=P(life is common), because knowing that life did evolve on earth can’t give us Bayesian evidence for or against the hypothesis that life is common.
That math is rather obviously wrong. You are so close here—just use Bayes.
Perhaps I should have used an approximately equal to symbol instead of an equals sign, to avoid confusion. And thanks for the detailed writeup. I would agree 100% if you substituted “planet X” for “earth”. Basically, I’m arguing that using ourselves as a data point is a form of the observational selection effect, just like survivorship bias.
Similarly, let’s suppose that we have a less discriminating test, mammography, that still has a 20% rate of false negatives, as in the original case. However, mammography has an 80% rate of false positives. In other words, a patient without breast cancer has an 80% chance of getting a false positive result on her mammography test. If we suppose the same 1% prior probability that a patient presenting herself for screening has breast cancer, what is the chance that a patient with positive mammography has cancer?
Group 1: 100 patients with breast cancer.
Group 2: 9,900 patients without breast cancer.
After mammography* screening:
Group A: 80 patients with breast cancer and a “positive” mammography*.
Group B: 20 patients with breast cancer and a “negative” mammography*.
Group C: 7920 patients without breast cancer and a “positive” mammography*.
Group D: 1980 patients without breast cancer and a “negative” mammography*.
The result works out to 80 / 8,000, or 0.01. This is exactly the same as the 1% prior probability that a patient has breast cancer! A “positive” result on mammography doesn’t change the probability that a woman has breast cancer at all. You can similarly verify that a “negative” mammography also counts for nothing. And in fact it must be this way, because if mammography has an 80% hit rate for patients with breast cancer, and also an 80% rate of false positives for patients without breast cancer, then mammography is completely uncorrelated with breast cancer.
In that example, the reason the posterior probability equals the prior probability is that the “test” isn’t causally linked with the cancer. You have to assume the same the same sort of thing for cases in which you are personally entangled. For example, if I watched my friend survive 100 rounds of solo Russian Roulette, then Baye’s theorem would lead me to believe that there was a high probability that the gun was empty or only had 1 bullet. However, if I myself survived 100 rounds, I couldn’t afterward conclude a low probability, because there would be no conceivable way for me to observe anything but 10 wins. I can’t observe anything if I’m dead.
Does what I’m saying make sense? I’m not sure how else to put it. Are you arguing that Baye’s theorem can still output good data even if you feed it skewed evidence? Or are you arguing that the evidence isn’t actually the result of survivorship bias/observation selection effect?
For example, if I watched my friend survive 100 rounds of solo Russian Roulette, then Baye’s theorem would lead me to believe that there was a high probability that the gun was empty or only had 1 bullet. However, if I myself survived 100 rounds, I couldn’t afterward conclude a low probability, because there would be no conceivable way for me to observe anything but 10 wins. I can’t observe anything if I’m dead.
Obviously you can’t observe anything if you are dead, but that isn’t interesting. What matter is comparing the various hypothesis that could explain the events.
The case where you yourself survive 100 rounds is somewhat special only in that you presumably remember whether you put bullets in or not and thus already know the answer.
Pretend, however that you suddenly wake up with total amensia. There is a gun next to you and a TV then shows a video of you playing 100 rounds of roulette and surviving—but doesn’t show anything before that (where the gun was either loaded or not).
What is the most likely explanation?
the gun was empty in the beginning
the gun had 1 bullet in the beginning
With high odds, option 1 is more likely. This survorship bias/observation selection effect issue you keep bringing up is completely irrelevant when comparing two rival hypothesis that both explain the data!
Here is another, cleaner and simpler example:
Omega rolls a fair die which has N sides. Omega informs you the roll comes up as a ‘2’. Assume Omega is honest. Assume that dice can be either 10 sided or 100 sided, in about the same ratio.
This is true for all cases where the observer is not noticeably entangled in a causal manner with the event they are trying to observe. Otherwise, the Observation Selection Effect can contribute false evidence. If we presumed that earth is typical, then there should also be life on Mars, and in most other solar systems. However, we wouldn’t ever have asked the question if we hadn’t evolved into intelligent life. The same thing that caused us to ask the question also caused the one blue-green data point that we have.
To illustrate: If you came across an island in the middle of the ocean, you might do well to speculate that such islands must be extremely common for you to come across one in the middle of the ocean. However, if you see smoke rising from beyond the horizon, and sail for days until finally reaching a volcanic island, you could not assign the same density to such volcanic islands as to ordinary islands. The same thing that caused you to observe the volcanic island also caused you to search for it in the first place. In the case of observable life, the Observation Selection Effect is much, much stronger because there’s no way we could conceivably have asked the question if we hadn’t come into existence somehow. P(life is common|life on earth)=P(life is common), because knowing that life did evolve on earth can’t give us Bayesian evidence for or against the hypothesis that life is common.
This changes things, potentially. Everything I’ve said in previous posts has been conditional on the assumption that we don’t live in a simulation. If we do, it is likely that our universe roughly resembles the real universe in some aspects. Perhaps they are running a precise simulation based on reality, or perhaps they are running a simulation based on a small change to reality, as an experiment. However, the motives of such a civilization are difficult to predict with any accuracy, so I suspect that the vast majority of possible hypotheses are things we haven’t even thought of yet. (unknown unknowns.) So, although your specific hypothesis becomes more likely if we are in a simulation, so do all other possible hypotheses predicting large numbers of simulations.
(2) Oops. I should have specified huge amounts of liquid water in the inner solar system. Mars has icecaps, and some of Jupiter’s moons are ice-balls, possibly with a liquid center. Earth has rather a lot of water, despite being well inside the frost line. When the planets were forming from an accretion disc, the material close to the sun would have caused any available water to evaporate, for the same reason there isn’t much water on the moon (at least outside a couple craters on the poles, which are in continuous shadow). Far enough out, though, and the sun’s heat is disperse enough that ice is stable; hence the icy moons of Jupiter. The best hypothesis we have is that some mechanism transported a large amount of water to Earth after it formed, perhaps via comets or asteroids. It just occurred to me that this might have been during the late heavy bombardment, or it might be just another coincidence. As you point out regarding our large moon, complex systems can be expected to have many, many 1-in-100 coincidences, simply because of statistics.
(3) Panspermia / Abiogenesis: it sounds like “Life Before Earth” isn’t a mainstream consensus, based on a couple comments below. I do know, however, that mainstream biology does teach Panspermia alongside Abiogenesis, so neither of them appears to be a clear winner by merit of scientific evidence. I’m not even sure of how to practically estimate their respective complexities, in order to use Occam’s Razor or Solomonoff Complexity to posit a reasonable prior. It would be nice to bound the problem enough to estimate the probabilities of both with sufficient accuracy to determine which is more likely. Until then though, I guess we’ll have to leave it at 50/50%.
The late heavy bombardment coinciding with the start of life is only explained by panspermia if (1) the rocks came from outside the solar system, which is unlikely given the huge amount of material, or (2) the rocks brought life from another source within our own solar system. This could also be explained if life required the large influx of matter/energy/climate disturbance/heating or whatever, or if life was continuously wiped out by the harsh environment until it finally started flourishing when it ended.
(8) Good point about extinction events being an evolutionary catalyst. Aside from possibly generating the primordial soup for Abiogenesis, snowball earths may have catalyzed early advancements, and mammals wouldn’t have been able to supersede dinosaurs without a certain meteor.
(9) Perhaps “abstract thought” isn’t the perfect term to use, since it is common enough to have become vague instead of precise. The stress should be on the word “abstract”, not on the word “thought”. Chimps and many other animals do have simple language, although no complex grammar structures. They can’t abstract an arbitrary series of motions necessary to make or use a tool into language, and communicate it without showing it. Abstract language is most of what I’m referring to, but not all of it.
This is likely why neanderthals went extinct, although we coexisted for quite a while. It still doesn’t explain why there aren’t octopus civilizations, since we haven’t changed that environment much until extremely recently. We haven’t evolved noticeably in hundreds of thousands of years, but haven’t colonized the planet until the last ~16,000 years. If our colonization is the only thing holding back other potential intelligent life, we’d expect to see elephants and parrots at least at the stone tool or fire level of technology. Why don’t octopus hunt with spears or lobster traps?
I skipped over a lot of your good points, largely because I see them as correct. I sill don’t buy the argument that life is common though, although I’d be less confident in any such assertion in either direction if we were in a simulation, just because of the huge amount of uncertainty that adds to things.
The origin of life on earth being coincident with the end of the late heavy bombardment could entirely be an artifact of the fact that no rock from before that time survives to this day. It could well be older on Earth. The reworking of the crust was not complete at any given time, it took hundreds of megayears and at any given time most of the crust would be undisturbed.
Water in the inner system has the complication of the fact that not only do you need to get water, you need to hold onto water. Small objects will not hold onto light molecules out of sheer gravity issues. Mars is not holding onto water or other atmospheric gases well at all because of both gravitational issues, and solar radiation sputtering the upper atmosphere off into space. Venus has all the gravity it could need, but A—no geomagnetic field (at least at this point in its history) and B—got so hot that all the water went into the atmosphere, where it gets cracked by radiation in the upper atmosphere and the hydrogen leaves (allowing the oxygen to react with volcanic gases giving you sulfuric acid and phosphoric acid and the like). The same process happens on Earth but the pool of atmospheric water is SO MUCH SMALLER due to all the liquid volume and the fact that we have this lovely temperature trap in our atmosphere that makes it condense out before it gets too high up that the rate is extremely small.
I would say the only time you can call humans ‘dominant’ is after the widespread adoption of agriculture, which was much more gradual than many people think—people were probably propagating seedless figs 20k years ago and much longer ago were altering the composition of plants and animals in various biomes just via their actions. Since agriculture got big we have become ecosystem engineers in the vein of bears, but rather larger in our effects. We have been creating new large-scale-symbiotic biomes where plants and animals flow matter and energy into each other and where we take care of dispersal rather than the plants themselves doing as much of it, for example. That’s the unique aspect of humanity. Since then we have also started breaking into non-biological forms of energy—raw sunlight, water flow, the black rocks that are basically 500 megayears of stored sunlight—and have been using those for our purposes too in addition to the biological energy flow that all other biomes deal with.
It will be very interesting to see how human ecology continues to change after the extremely concentrated energy sources that represent most of the power we have used over the last 200 years go away. The end result might be very big but might not have the sheer flux of inefficient extractive growth—think weeds colonizing a freshly plowed field, versus an old-growth forest.
Dear CellBioGuy, what is your intuition on what preceded procaryotes?
That is a very interesting question and one which there’s constant research going into.
A few initial points. First, its becoming clearer and clearer that ‘prokaryotes’ is a very poor grouping to use for much of anything. The bacteria most of us think of are the smaller, faster-replicating members of the eubacteria. There’s also the archaebacteria, which are deeply and fundamentally different from the eubacteria in their membrane composition, cell wall structure, DNA organization, and transcription machinery.
Second, it’s becoming more and more clear that the eukaryotes are indeed the result of an early union of eubacteria and archaebacteria. I saw some very cool research at a conference last December bolstering the “eocyte hypothesis”—the idea that the Eukaryotic nuclear genome roots in one particular spot of the archaebacterial tree plus loads of horizontal gene transfer from the eubacteria that became the mitochondria. You can’t root it there just by aligning things, this was long enough ago that base sequence is effectively randomized, you need to look at what sorts of proteins exist, characters that change very rarely as opposed to mere sequence, and its a very hard question that has required a LOT of sequence data from a LOT of organisms. Most of our DNA structure and transcription and some of our protein processing looks like the archaebacteria, but basically all of our metabolism looks like the eubacteria. This is interesting in the light of recent discoveries of symbiotic pairings of archaebacteria and eubacteria in nature in which they exchange metabolic products.
Anyways, the eubacteria and archaebacteria have deeply different transcription machinery and make their membranes in fundamentally different ways. Central carbon metabolism is all but identical though as is a lot of other pathways, and the core biochemistry. I’ve seen work proposing that the eubacteria and archaebacteria may have diverged before living things managed to synthesize their own membrane components rather than scavenging them from the environment. I’ve also seen interesting work to the effect that certain clay minerals can assemble fatty acids and other such membrane-building substances from acetate under the proper energetic conditions.
There’s also a lot of diverstiy in DNA and RNA processing methods that isn’t in any of the cellular life – there are truly bizarre ways of doing this that you only find in viruses. Viruses mutate incredibly rapidly and so you cannot try to root them anywhere, they change too fast. That being said there are proposals that they may be primordial, elements of the very wide range of possible nucleic acid processing mechanisms that existed before the current forms of cellular life really were established and took off. The eubacterial and archaebacterial models may have taken off with remnants of the rest winding up parasitizing them.
Rampant horizontal transfer of genes, especially early when cell identity might not have been so strong, makes all this very complicated.
There’s a school of thought in origin of life research that autocatalytic metabolism was important, and another that replicating polymers were important. The former posits that metal-ion driven cyclical reactions like the citric acid cycle can take off and take over, and wind up producing lots of interesting chemical byproducts that can then capture it and become discrete self-replicating units. The latter points out that elongating polymers in membrane bubbles speed the growth and splitting of these bubbles. They’re both probably important. It should be noted too that these ideas intersect – one of the popular metabolic ideas, polyphosphate, is actually represented in our nucleic acids. Polyphosphate is an interesting substance that can be built up by the right chemial reactions, and can drive other ones when it breaks down. Every ATP, GTP, etc is a nice chemical handle on the end of a chain of three phosphates – a short polyphosphate. By breaking down those polyphosphates you build polymers.
Proteins obviously came very early and gave a huge advantage, and the genetic code is damn near universal with all deviations from the standard one obvioulsy coming in after the fact. Whatever could make proteins probably took over quickly. The initial frenzy, whatever it was, probably eventually lead to a diverse population of compartments processing their nucleic acids in diverse ways and sending pieces of their codes back and forth, which eventually gained advantages by building their own membranes, and eventually cell walls, in different ways. Some of these populations probably took off like mad, making the eubacteria and archaebacteria, and others remained only as horizontally transferred elements like viruses or transposons or the like.
Written in a hurry, may be edited or clarified/extended later.
Of interest!
Even more recent evidence for the eocyte hypothesis!
http://www.the-scientist.com/?articles.view/articleNo/42902/title/Prokaryotic-Microbes-with-Eukaryote-like-Genes-Found/
A clade of archaebacteria found via metagenomics at an undersea vent (uncultured). Contains huge numbers of eukaryotic characteristic genes that are important for formerly eukaryotic specific functions. The eukaryotes cluster within this clade rather than as a sister clade.
That math is rather obviously wrong. You are so close here—just use Bayes.
We have 2 mutually exclusive models: life is common, and life is rare. To be more specific, lets say that the life is common theory posits that life is a 1 in 10 event, the life is rare theory posits that life is a 1 in a billion event.
Let’s say that our priors are P(life is common) = 0.09, and P(life is rare) = 0.91
Now, our observation history over this solar system tells us that life evolved on earth—and probably only complex life on earth, although there may be simple life on mars or some of the watery moons.
As we are just comparing two models, we can compare likelihoods
P(life is common | life on earth) ]= P(life on earth | life is common) P(life is common) = 0.09 * 0.1 = 0.009 ~ 10^-2
P(life is rare | life on earth) ]= P(life on earth | life is rare) P(life is rare) = 10^-9 * 0.91 ~ 10^-9
To convert to actual probabilities we would need to divide by P(life on earth), but that doesn’t really matter because it is a constant normalizing factor.
I agree with your general analysis here, although it is important to remember that the full hypothesis space is always infinite. For tractable inference, we focus on a small subset of the most promising theories/models.
When considering the wide space of potential simulators, we must focus on key abstractions. For example, we can focus on models in which advanced civs have convergent instrumental reasons for creating large numbers of simulations. I am currently aware of a couple of wide classes of models that predict lots of sims. Besides aliens simulating other aliens, our descendants could have strong motivations to simulate us—as a form of resurrection for example, in addition to the common motivator for improving world models. There is also the possibility of creating new artificial universes, in which case there may be interesting strong motivators to create lots of universes and lots of simulations as a precursor step.
No—that paper is not even really mainstream. I mentioned it as an example of the panspermia model and the resulting potentially expanded timeframe for the history of life. If life is really that old, then it becomes less likely that a single early elder civ colonized the galaxy early and dominated.
Perhaps I should have used an approximately equal to symbol instead of an equals sign, to avoid confusion. And thanks for the detailed writeup. I would agree 100% if you substituted “planet X” for “earth”. Basically, I’m arguing that using ourselves as a data point is a form of the observational selection effect, just like survivorship bias.
As for the math, I’ll pull an example from An Intuitive Explanation of Bayes’ Theorem:
In that example, the reason the posterior probability equals the prior probability is that the “test” isn’t causally linked with the cancer. You have to assume the same the same sort of thing for cases in which you are personally entangled. For example, if I watched my friend survive 100 rounds of solo Russian Roulette, then Baye’s theorem would lead me to believe that there was a high probability that the gun was empty or only had 1 bullet. However, if I myself survived 100 rounds, I couldn’t afterward conclude a low probability, because there would be no conceivable way for me to observe anything but 10 wins. I can’t observe anything if I’m dead.
Does what I’m saying make sense? I’m not sure how else to put it. Are you arguing that Baye’s theorem can still output good data even if you feed it skewed evidence? Or are you arguing that the evidence isn’t actually the result of survivorship bias/observation selection effect?
Obviously you can’t observe anything if you are dead, but that isn’t interesting. What matter is comparing the various hypothesis that could explain the events.
The case where you yourself survive 100 rounds is somewhat special only in that you presumably remember whether you put bullets in or not and thus already know the answer.
Pretend, however that you suddenly wake up with total amensia. There is a gun next to you and a TV then shows a video of you playing 100 rounds of roulette and surviving—but doesn’t show anything before that (where the gun was either loaded or not).
What is the most likely explanation?
the gun was empty in the beginning
the gun had 1 bullet in the beginning
With high odds, option 1 is more likely. This survorship bias/observation selection effect issue you keep bringing up is completely irrelevant when comparing two rival hypothesis that both explain the data!
Here is another, cleaner and simpler example:
Omega rolls a fair die which has N sides. Omega informs you the roll comes up as a ‘2’. Assume Omega is honest. Assume that dice can be either 10 sided or 100 sided, in about the same ratio.
What is the more likely value of N?
100
10
Here is my solution:
priors: P(N=100) = 1, P(N=10) = 1
P(N=100 | roll(N) = 2) = P(roll(N)=2 | N=100) P(N=100) = 0.01
P(N=10 | roll(N) = 2) = P(roll(N)=2 | N = 10) P(N=10) = 0.1
So N=10 is 10 times more likely than N= 100.