Very interesting. Thank you for sharing this theory.
I had two thoughts. The first is: “Doesn’t radiation cause cancer? Isn’t this effect well established with evidence?”. Because if radiation does cause cancer then that is strong evidence that the DNA theory is true of at least some cancers. (Because radiation cannot spread a fungus).
My second thought (which I agree is in some tension with the radiation one), is that, even if I subscribe to a DNA theory of cancer, I don’t have to imagine that every tumour has a mutation (relative to the rest of the organism), or that tumour cells are unable to produce healthy embryos without a cancer. To use a software analogy, lets imagine we have a piece of software with a bug. We have all played a computer game where things are basically fine but there is that one time you ended up halfway inside a wall because of some collision error thing. You never worked out quite what did it that time, but the game was usually fine.
When a piece of software shows that collision bug, we don’t need to assume that a cosmic ray has flipped a bit in the software. We can check that the code is the same before and after we saw the collision error. This doesn’t mean we are going to see collision errors every single time we play that computer game, it just means that the game has a bug that can appear in some limited situations. Similarly, I can imagine that many organisms contain “bugs” in their DNA (the DNA they were born with, undamaged) and that some of these bugs only express themselves rarely, when specific circumstances arise, and sometimes the result of the “glitch” is cancer. In this model the tumours are not mutated. This model is consistent with the idea that radiation and so on can make cancer more likely, as flipping a bunch of bits in a piece of software is much more likely to introduce more bugs than to reduce the number. But it also seems consistent with some tumours being genetically identical to the rest of the organism. The main prediction of this sort of model would be a strong inherited tendency for certain cancers, especially for identical twins.
As a final thought. If the fungus theory is correct, it doesn’t seem like it would be impossibly hard for someone to find some of the fungus cells in mouse A. Look at them under a microscope, “Yes, fungus all right.” and then use them to give cancer to a bunch of other mice. So the fungus theory (unlike my speculations above) has the great advantage of seeming to be very testable.
The tenet that radiation cannot spread a fungus is incorrect. Fungi radiotrophic effects in the literature is exactly aligned with radiation making cancer worse. See cryptococcus neoformans and ionizing radiation triggering a melanin synthesis virulence loop. See the lichen that grew on the international space station. Other fungi including sacchyromyces are also included here. You can match this phenomenon to reports of mammogram induced cancers of which there are studies available.
Very interesting. Thank you for sharing this theory.
I had two thoughts. The first is: “Doesn’t radiation cause cancer? Isn’t this effect well established with evidence?”. Because if radiation does cause cancer then that is strong evidence that the DNA theory is true of at least some cancers. (Because radiation cannot spread a fungus).
My second thought (which I agree is in some tension with the radiation one), is that, even if I subscribe to a DNA theory of cancer, I don’t have to imagine that every tumour has a mutation (relative to the rest of the organism), or that tumour cells are unable to produce healthy embryos without a cancer. To use a software analogy, lets imagine we have a piece of software with a bug. We have all played a computer game where things are basically fine but there is that one time you ended up halfway inside a wall because of some collision error thing. You never worked out quite what did it that time, but the game was usually fine.
When a piece of software shows that collision bug, we don’t need to assume that a cosmic ray has flipped a bit in the software. We can check that the code is the same before and after we saw the collision error. This doesn’t mean we are going to see collision errors every single time we play that computer game, it just means that the game has a bug that can appear in some limited situations. Similarly, I can imagine that many organisms contain “bugs” in their DNA (the DNA they were born with, undamaged) and that some of these bugs only express themselves rarely, when specific circumstances arise, and sometimes the result of the “glitch” is cancer. In this model the tumours are not mutated. This model is consistent with the idea that radiation and so on can make cancer more likely, as flipping a bunch of bits in a piece of software is much more likely to introduce more bugs than to reduce the number. But it also seems consistent with some tumours being genetically identical to the rest of the organism. The main prediction of this sort of model would be a strong inherited tendency for certain cancers, especially for identical twins.
As a final thought. If the fungus theory is correct, it doesn’t seem like it would be impossibly hard for someone to find some of the fungus cells in mouse A. Look at them under a microscope, “Yes, fungus all right.” and then use them to give cancer to a bunch of other mice. So the fungus theory (unlike my speculations above) has the great advantage of seeming to be very testable.
Anything that causes cell damage and inflammation has effects that sometimes make cells more vulnerable to pathogens.
The tenet that radiation cannot spread a fungus is incorrect. Fungi radiotrophic effects in the literature is exactly aligned with radiation making cancer worse. See cryptococcus neoformans and ionizing radiation triggering a melanin synthesis virulence loop. See the lichen that grew on the international space station. Other fungi including sacchyromyces are also included here. You can match this phenomenon to reports of mammogram induced cancers of which there are studies available.
You are correct, the fungus theory is testable.