If there were a perfect correlation between choosing to one-box and having the one-box gene (i.e., everyone who one-boxes has the one-box gene, and everyone who two-boxes has the two-box gene, in all possible circumstances), then it’s obvious that you should one-box, since that implies you must win more. This would be similar to the original Newcomb problem, where Omega also perfectly predicts your choice. Unfortunately, if you really will follow the dictates of your genes under all possible circumstances, then telling someone what she should do is useless, since she will do what her genes dictate.
The more interesting and difficult case is when the correlation between gene and choice isn’t perfect.
If there were a perfect correlation between choosing to one-box and having the one-box gene (i.e., everyone who one-boxes has the one-box gene, and everyone who two-boxes has the two-box gene, in all possible circumstances), then it’s obvious that you should one-box, since that implies you must win more. This would be similar to the original Newcomb problem, where Omega also perfectly predicts your choice. Unfortunately, if you really will follow the dictates of your genes under all possible circumstances, then telling someone what she should do is useless, since she will do what her genes dictate.
The more interesting and difficult case is when the correlation between gene and choice isn’t perfect.