Being small enough to freeze solid quickly is a nonstarter.
Cells filling themselves up with trehalose (disaccharide that in many organisms including waterbears and my lab yeast serves as both a fast-degrading energy store [faster than glycogen] and protection against denaturing proteins during both desiccation and freezing) under stress is more plausible but runs afoul of the fact that large animals only have so much soluble sugar at any given time and can’t make sugars from lipids—in many cases of organisms that use it as a protective feature it becomes like 10% or more of their weight.
Trying to eliminate the inflammatory response to hypoxia? No idea if that’s plausible without causing immune system issues.
Being small enough to freeze solid quickly is a nonstarter.
Cells filling themselves up with trehalose (disaccharide that in many organisms including waterbears and my lab yeast serves as both a fast-degrading energy store [faster than glycogen] and protection against denaturing proteins during both desiccation and freezing) under stress is more plausible but runs afoul of the fact that large animals only have so much soluble sugar at any given time and can’t make sugars from lipids—in many cases of organisms that use it as a protective feature it becomes like 10% or more of their weight.
Trying to eliminate the inflammatory response to hypoxia? No idea if that’s plausible without causing immune system issues.