If aminoguanidine temporarily reverses arterial stiffening, and if arterial stiffening reduces paravascular cerebral fluid flow, which in turn inhibits clearance of Alzheimer’s-causing proteins, then aminoguanidine could potentially work as an Alzheimer’s drug if it can be transported to the right area. The severity of Alzheimer’s might even justify taking aminoguanidine despite the side-effects.
And encouragingly, moderate-dose aminoguanidine in conjunction with pyridoxine was found to maintain the neuroprotective effect while eliminating appreciable toxicity. There are several papers on pyridoxal-aminoguanidine adducts, and on pyrodoxal phosphate.
I’ve only read a few abstracts, so I can’t vouch for the quality of the evidence so far, but it’s nice to see that the gears-level reasoning in your model can successfully predict existing lines of research.
If aminoguanidine temporarily reverses arterial stiffening, and if arterial stiffening reduces paravascular cerebral fluid flow, which in turn inhibits clearance of Alzheimer’s-causing proteins, then aminoguanidine could potentially work as an Alzheimer’s drug if it can be transported to the right area. The severity of Alzheimer’s might even justify taking aminoguanidine despite the side-effects.
Indeed, there is some recent research into applying aminoguanidine to Alzheimer’s. It appears that aminoguanidine does penetrate the blood-brain barrier via diffusion. And there are several studies, mainly from the last 5 years, exploring aminoguanidine as a neuroprotectant against dementia/Alzheimer’s in murine models.
And encouragingly, moderate-dose aminoguanidine in conjunction with pyridoxine was found to maintain the neuroprotective effect while eliminating appreciable toxicity. There are several papers on pyridoxal-aminoguanidine adducts, and on pyrodoxal phosphate.
I’ve only read a few abstracts, so I can’t vouch for the quality of the evidence so far, but it’s nice to see that the gears-level reasoning in your model can successfully predict existing lines of research.