I am a bit confused why some of these theories would be so hard to test?
It seems like some core pathways that seem like they wouldn’t be reversible even in naive stem cells under any circumstances (like transposons copying themselves successfully), could possibly be tested by checking if clones derived from older cells age faster or something along those lines? The same goes for children from older parents? (Not sure to which extent that test would be made harder by all the mechanisms keeping the germ line immortal)
I am a bit confused why some of these theories would be so hard to test? It seems like some core pathways that seem like they wouldn’t be reversible even in naive stem cells under any circumstances (like transposons copying themselves successfully), could possibly be tested by checking if clones derived from older cells age faster or something along those lines? The same goes for children from older parents? (Not sure to which extent that test would be made harder by all the mechanisms keeping the germ line immortal)