I see, thanks. Could approaches like Horvath’s phenoage/grimage (which I think go after methylation) be good enough proxies for the “transposon clock” or somewhat correlated but different things?
Methylation is the primary transposon suppression mechanism, so methylation levels would tell us the extent to which transposons are suppressed at a given instant, but not the number of live transposon copies.
I see, thanks. Could approaches like Horvath’s phenoage/grimage (which I think go after methylation) be good enough proxies for the “transposon clock” or somewhat correlated but different things?
Methylation is the primary transposon suppression mechanism, so methylation levels would tell us the extent to which transposons are suppressed at a given instant, but not the number of live transposon copies.