Interestingly, there seem to be some groups for which modafinil does little or nothing, and this ineffectiveness may not be due to counterfeit product or poor self-monitoring, but genetics:
“…Two-time 100 mg modafinil potently improved vigor and well-being, and maintained baseline performance with respect to executive functioning and vigilant attention throughout sleep deprivation in Val/Val genotype subjects but was hardly effective in subjects with the Met/Met genotype.”
The genotype variation specifically refers to the Rs4680 SNP, which is one of the SNPs that services like 23andMe test for.
Crap, I’m Met/Met! Thanks for saving me some money though.
I’m curious too. I did my MSc thesis on pharmacogenomics (pdf), and am now generally skeptical of this sort of result. I’ll have a closer look at the paper and make a decision. Any tips on procurement if the decision goes that way?
I am well aware of that site, have received modafinil from it, and have even corresponded with the owner; ignorance of specific websites was not the point I was making.
I just felt like the speed of my answer should still be of some benefit, and I wasn’t aware that you had gained the knowledge of its existence in the month hence your previous comment.
From your modafinil link:
Crap, I’m Met/Met! Thanks for saving me some money though.
You’re welcome. You could get some and try anyway to see what happens—I’ve long wondered how reliable these SNP findings are.
I’m curious too. I did my MSc thesis on pharmacogenomics (pdf), and am now generally skeptical of this sort of result. I’ll have a closer look at the paper and make a decision. Any tips on procurement if the decision goes that way?
Google Adrafinil. It works very well for me. It is legal and unregulated in USA and some other places.
Nothing that I haven’t already written down or that a LWer shouldn’t be able to figure out.
mymodafinil.com
I am well aware of that site, have received modafinil from it, and have even corresponded with the owner; ignorance of specific websites was not the point I was making.
I just felt like the speed of my answer should still be of some benefit, and I wasn’t aware that you had gained the knowledge of its existence in the month hence your previous comment.