Yep, and several other specialist. We ruled out everything else, which left me with a vague diagnosis of nonspecific, as-yet idiopathic food sensitivity.
Ugh! I’m just realizing you haven’t even been told if Gluten-intolerance is the underlying etiology which is understandable frustrating...apologies. I looked closer at some other NCBI articles and we really don’t have a good understanding of gluten intolerance other than it appears related to some underlying autoimmune disorder. That leaves you 1) experimenting with eliminating gluten, which it sounds like you‘re already working on, to see if there’s any correlation with gluten intake at all; and 2) getting tested for the various biomarkers folks have suggested below.
There is a recent discussion article I read in the NEJM on “An Allergic Basis for Abdominal Pain” discussing some recent research on Allergies and IBS you may or may not find useful. https://www.nejm.org/doi/full/10.1056/NEJMcibr2104146?rss=searchAndBrowse Let me know you want to read it but can’t access it and I’ll be happy to email you a copy of my pdf.
Another thought is if your specialists have mentioned small intestine bacterial overgrowth (SIBO)? I’ve had vague IBS issues that had worsened over the past year that we’d been working on without any resolution. A physician friend suggested I try a nutritional supplement called Atrantil which my GI doc said was worth trying since nothing else was working. Short story is it helped which led to trying a course of xifaxin/neomycin for SIBO that I’ve had good results with. Problematic is that diagnosing SIBO isn’t really good and is trial/error of trying various antibiotics.
Yep, and several other specialist. We ruled out everything else, which left me with a vague diagnosis of nonspecific, as-yet idiopathic food sensitivity.
Ugh! I’m just realizing you haven’t even been told if Gluten-intolerance is the underlying etiology which is understandable frustrating...apologies. I looked closer at some other NCBI articles and we really don’t have a good understanding of gluten intolerance other than it appears related to some underlying autoimmune disorder. That leaves you 1) experimenting with eliminating gluten, which it sounds like you‘re already working on, to see if there’s any correlation with gluten intake at all; and 2) getting tested for the various biomarkers folks have suggested below.
There is a recent discussion article I read in the NEJM on “An Allergic Basis for Abdominal Pain” discussing some recent research on Allergies and IBS you may or may not find useful. https://www.nejm.org/doi/full/10.1056/NEJMcibr2104146?rss=searchAndBrowse Let me know you want to read it but can’t access it and I’ll be happy to email you a copy of my pdf.
Another thought is if your specialists have mentioned small intestine bacterial overgrowth (SIBO)? I’ve had vague IBS issues that had worsened over the past year that we’d been working on without any resolution. A physician friend suggested I try a nutritional supplement called Atrantil which my GI doc said was worth trying since nothing else was working. Short story is it helped which led to trying a course of xifaxin/neomycin for SIBO that I’ve had good results with. Problematic is that diagnosing SIBO isn’t really good and is trial/error of trying various antibiotics.
Please excuse typos & autocorrect strangeness
Thanks for your reply!
No one mentioned the idea of SIBO, and doesn’t sound like it would really match my symptoms, but something I’ll keep in mind.