The main concern I had was that it leads to a development of polyethylene glycol resistence. After talking this through with a doctor, I now believe that 1-2 doses of the vaccine are unlikely to have a significant effect but still some that giving significantly more doses (for example 2 every year to target changing viruses) could lead to such an effect.
I already fully isolate, and would only value my freedom a bit, whereas I value my health a lot.
Human contact is very important for human health. The idea that you can fully isolate without paying a price for it in health seems questionable to me. Humans are not constructed to live healthy lifes in isolation from other humans.
The administration of PEGylated drugs can lead to the production of anti-PEG antibodies(anti-PEG immunoglobulin M (IgM)) and immune response (Figure 1) [30]. Due to these phenomena,the PEG-conjugation of drugs/NPs often only provides a biological advantage during the first dose of a treatment course. By the second dose, the PEGylated agents have been recognized by themononuclear phagocyte system in the spleen and liver and are rapidly cleared from circulation.
Polyethylene glycol or PEG is the lipid with which the mRNA is coated and it seems the body starts attacking it with repeated treatments.
This means repeated usage of drugs that contain PEG reduces the efficiency per dose and increases side effects. However after speaking with a doctor who told me a lot about the involved gears, I don’t think this is a huge deal for giving a human two doses of an mRNA vaccine.
The main concern I had was that it leads to a development of polyethylene glycol resistence. After talking this through with a doctor, I now believe that 1-2 doses of the vaccine are unlikely to have a significant effect but still some that giving significantly more doses (for example 2 every year to target changing viruses) could lead to such an effect.
Human contact is very important for human health. The idea that you can fully isolate without paying a price for it in health seems questionable to me. Humans are not constructed to live healthy lifes in isolation from other humans.
well, I should unpack “fully isolate” (I meant fully isolate from the virus):
I isolate with another human
I video-chat with multiple humans
I chat in person with other humans outside with 3 meters distance or insider with a full-face mask :)
What is polyethylene glycol resistance? Google isn’t turning much up. Or do you mean sensitivity / allergy?
Antibody buildup against polyethylene glycol or PEG. One issue of concern was voiced in The Importance of Poly(ethylene glycol) Alternativesfor Overcoming PEG Immunogenicity in DrugDelivery and Bioconjugation:
Polyethylene glycol or PEG is the lipid with which the mRNA is coated and it seems the body starts attacking it with repeated treatments.
This means repeated usage of drugs that contain PEG reduces the efficiency per dose and increases side effects. However after speaking with a doctor who told me a lot about the involved gears, I don’t think this is a huge deal for giving a human two doses of an mRNA vaccine.