The new lipid nanoparticle delivery method can potentially target a much wider range of cells than older modalities. Any cell can ingest an LPN and start displaying spike protein epitopes. All the cells that are not professional presenter cells and do not have MHC-2 complexes will be destroyed by immune system. Some critical, sensitive, hard to replace cells might be so killed at random if enough LPN get into systemic circulation which can occur if for example a needle pierces a blood vessel during vaccination and a large portion of LPN spills into the veins. The chance of this type of accident and the chance that significant damage to your organs will be done as a result is not very big, but it is a risk which you will be taking every time you vaccinate.
The new lipid nanoparticle delivery method can potentially target a much wider range of cells than older modalities. Any cell can ingest an LPN and start displaying spike protein epitopes. All the cells that are not professional presenter cells and do not have MHC-2 complexes will be destroyed by immune system. Some critical, sensitive, hard to replace cells might be so killed at random if enough LPN get into systemic circulation which can occur if for example a needle pierces a blood vessel during vaccination and a large portion of LPN spills into the veins. The chance of this type of accident and the chance that significant damage to your organs will be done as a result is not very big, but it is a risk which you will be taking every time you vaccinate.