I’m not a biologist, and bodies are complicated enough that I’d like an answer to this too.
But to a first glance from a layman: I have a hard time understanding what mechanisms there might be, especially age-dependent ones. The sugars, salts, acids, and stabilizers all either occur naturally in the body or have been used medically long enough to have their risk profiles known. I don’t know about the specific lipids used, can’t comment there. mRNA only survives in the body for a matter of hours, after that what’s present is just the proteins you made from the mRNA, which should work the same way as identical viral-derived proteins would, generating an immune response by the same mechanism.
I’m not a biologist, and bodies are complicated enough that I’d like an answer to this too.
But to a first glance from a layman: I have a hard time understanding what mechanisms there might be, especially age-dependent ones. The sugars, salts, acids, and stabilizers all either occur naturally in the body or have been used medically long enough to have their risk profiles known. I don’t know about the specific lipids used, can’t comment there. mRNA only survives in the body for a matter of hours, after that what’s present is just the proteins you made from the mRNA, which should work the same way as identical viral-derived proteins would, generating an immune response by the same mechanism.